Carcinosarcoma of Ovary, It’s Histopathological, Management and Prognostic Analysis with Review of Literature | Chapter 15 | New Insights into Disease and Pathogen Research Vol. 2
Carcinosarcoma is a mixed malignant
biphasic tumour representing a rare entity and comprises of both epithelial and
mesenchymal components. Primary ovarian carcinosarcoma is a rare neoplasm with
a number of cases reported in the literature in the hundreds. It accounts for
less than 1% of all ovarian tumours. These tumours are usually diagnosed at
older age and advanced stage. It has aggressive clinical behaviour and survival
depends on stage at presentation. Radiological imagings cannot differentiate
carcinosarcomas from other ovarian cancers. Diagnosis is based upon histological
findings. Cytoreductive debulking surgery is a crucial part in the treatment of
carcinosarcoma of ovary. The role of adjuvant chemotherapy regimen is still
controversial. Combination chemotherapy with taxane and platinum based regimen
or ifosfamide and platinum based regimen are considered as adjuvant treatment.
Despite aggressive treatment modalities such as surgery and chemotherapy, the
outcome is poor. Response to therapy and overall survival for carcinosarcoma
are poor in comparison to that of epithelial ovarian malignancies. Due to
rarity of the disease, such poor prognosis needs collaboration of studies with
molecular analysis to obtain new therapeutic guidelines to improve survival of
the patients.
Author(s) Details
Dr. Priyanka Priyadarshini
Department of Obstetrics and
Gynaecology, Calcutta National Medical College and Hospital, Kolkata, West
Bengal, 700014, India.
Dr. Tapan Kumar Sahoo
Department of Radiotherapy,
Acharya Harihara Regional Cancer Centre, Cuttack, Odisha, 753007, India.
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