Evaluation of the Haemostatic Activities of Sida corymbosa in Rats | Chapter 02 | Modern Advances in Pharmaceutical Research Vol. 3
Aims:
To evaluate the anti-haemorrhagic activity of the leaf extract of Sida
corymbosa in Wistar albino rats, a plant used to arrest bleeding in
ethnomedical practices.
Methods: The acute toxicity test was
carried out in rats. The haemostatic activities of the extract were
investigated using the tail bleeding time and amount of bleeding in rats; effects
on haematological parameters were also evaluated in Wistar rats. Preliminary
phytochemical analysis was conducted to detect the phytoconstituents of the
extract of Sida corymbosa.
Results: In this study, the oral LD50
of the extract was found to be greater than 5 g/kg. Administration of the
extract to rats for 14 days produced a dose-dependent and significant (P≤0.05)
decrease in bleeding time and quantity of blood loss in pre-treated rats. On
oral administration of the extract, the effects of the treatment on
haematological parameters – White blood cells, Red blood cell, haemoglobin
concentration were not significantly different from control.
Conclusion: This study has shown
that Sida corymbosa has constituents with anti-haemorrhagic properties in rats
thereby providing scientific validation for the ethnomedical use of the plant
in bleeding control.
Author(s) Details
Lucy B. John-Africa
Department of Pharmacology
and Toxicology, National Institute for Pharmaceutical Research and Development,
Idu Abuja, Nigeria.
Mercy Aboh
Department of Microbiology,
Virology and Biotechnology National Institute for Pharmaceutical Research and
Development, Idu Abuja, Nigeria.
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