Skip to main content

Research on Evaluation of the Effect of Crude Extract of Datura innoxia on the Cardiovascular Action of Detomidine in Rabbits | Chapter 8 | Trends in Pharmaceutical Research and Development Vol. 1

Datura innoxia indigenous shrub in South Asia region belongs to the family Solanaceae which contains medicinal important alkaloids (hyoscine, atropine, hycosamine, etc). Thirty adult rabbits of mixed breed, male and female were pretreated with 0.1 mg/500 mg of crude extract (1% of dimethyl sulfoxide (DMSO) solution) and injected 5 min later with 0.01 mg/500 mg of detomidine (group A, n=15) or Saline (group B, n=15). Mean arterial pressure, measurements and electrocardiography were performed for 65 min. After injecting crude extract of D. innoxia, the heart rate was increased by 45 and 46.34% in groups A and B, respectively. Heart rate remained increased after the injection of detomidine returning to base line values after 15 min. No increase in the mean arterial  pressure (MAP) was noted in group B rabbits. Crude extract shortened PR and QT interval in both groups but after detomidine, PR and QT interval were enlarged significantly at the end of the experiment. The second degree atrioventricular was blocked in two rabbits after 40 min only in group B. It was concluded that alkaloid present in D. innoxia prevented detomidine induced Bradycardia  and might be useful during combination against the Bradycardia induced by alpha-2 agonist in the rabbits.

Author(s) Details
Dr. S. U. Rehman
Faculty of Sciences, University of Central Punjab, Lahore, Pakistan.

View Book : - http://bp.bookpi.org/index.php/bpi/catalog/book/156

Labels:

Comments

Post a Comment

Popular posts from this blog

Greening Regional Airports: A Vision for Carbon Neutral Infrastructure | Chapter 12 | Contemporary Perspective on Science, Technology and Research Vol. 3

 This study provides an overview of the energy demand of a regional airport, divided into individual time horizons. The electrification of aircraft systems raises the question of whether airports will be among the largest electricity consumers in our infrastructure in the future. Sustainability and especially emission reductions are significant challenges for airports that are currently being addressed. The Clean Sky 2 project GENESIS addresses the environmental sustainability of hybrid-electric 50-passenger aircraft systems in a life cycle perspective to support the development of a technology roadmap for the transition to sustainable and competitive electric aircraft systems. This article originates from the GENESIS research and describes various options for ground power supply at a regional airport. Potential solutions for airport infrastructure with a short (2030), medium (2040), and long (2050) time horizon are proposed. In addition to the environmental and conservation benefi...
Post a Comment
Read more

Alkali Element Modification of Glucose Molecules as a Method to Dissolve Cancer Cells | Chapter 12 | New Visions in Medicine and Medical Science Vol. 4

  The present study highlights about alkali element modification of glucose molecules as a method to dissolve cancer cells. The central regulation of the mechanisms governing cell proliferation has little effect on cancer cells. Cancer cells are entirely independent of the central command and divide and proliferate on their own, making it challenging to activate their response mechanism. Precisely, this is the reason why they are at risk to the health of humans and/or any biological entities. Instead of trying to reconnect the central command of the growth control mechanism to cancer cells that are already out of the range, we present a method of using the cancer cell’s own irresponsive and uncontrolled growth mechanism to their disadvantage and destroy the cancer cells. We found that this is achievable in an atomic/molecular level study of the glucose molecule, which is the primary food source used for growth and energy generation by all cells in the body, including the cancer cel...
Post a Comment
Read more

A Multi-factorial Analysis of the Factors Affecting Elementary Students’ Interest in Physical Education Considering Students’ Ethnicity and Gender | Chapter 5 | New Visions in Medicine and Medical Science Vol. 4

  Background: Student attitudes toward education are of great concern to educators around the world. Fostering Student’s positive interest in physical education is of great concern in academia. More importantly, the rationale as to why one would maintain a positive interest in physical education is of concern. These topics have been widely researched. However, the comparison of gender and ethnicity as it relates to students’ interest in physical education is a novel investigation. The purpose of this study was to ascertain the relationship between elementary student’s interest in physical education considering gender, ethnicity, curricular and teacher influences, and student’s perceived competency. Methods: Participants included 99 fifth-grade elementary school students (62 males, 37 females). Participant selection was conducted by utilizing 6 intact physical education classes from a single culturally diverse elementary school. Racial and ethnic distribution for fifth graders c...
Post a Comment
Read more