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Intravenous Dexmedetomidine Versus Paracetamol for Postoperative Pain Relief in Laparoscopic Surgery: A Comparative Study | Chapter 11 | New Frontiers in Medicine and Medical Research Vol. 7

Background: Acute discomfort during the perioperative period is deleterious to the postoperative result, and appropriate analgesia improves the outcome. It raises the body's sympathetic response, resulting in increased oxygen consumption, increased risk of deep vein thrombosis due to immobility, and pulmonary embolism.

Methods: Sixty ASA I/II patients between the ages of 18 and 65 who underwent laparoscopic cholecystectomy and appendicectomy were randomly assigned to one of two groups. Patients with an ASA III/IV rating, those who had already received opioid or alpha 2 agonist treatment, and those who needed substantial surgical dissection were excluded. Prior to extubation, Group D got 1 g/kg IV Dexmedetomidine over 10 minutes, followed by 0.2-0.7 g/kg/hr, while Group P received 15 mg/kg IV Paracetamol. After extubation, patients' hemodynamics were followed and their VAS scores were measured for the next 24 hours. The time interval between the requirement of the first dosage of rescue analgesia and the administration of rescue analgesia (IV tramadol 1 mg/kg) was monitored.

Results: Twelve patients in group D required rescue analgesia, compared to four patients in group P (40 percent vs. 13.3%; P=0.02). Both groups had similar VAS scores, with group P indicating a trend toward a low score. Group P had a longer median duration to provide the first dose of rescue analgesia (134.42 + 12.67 min vs 82.76 + 9.38 min; P=0.001). Group D had a greater rate of bradycardia and hypotension (20 percent vs. 3.3 percent; P=0.04).

Conclusion: In short surgical operations, paracetamol is superior to dexmedetomidine for analgesia and should be used as part of a multimodal analgesic strategy.


Author (S) Details

Manjula Sarkar
Department of Cardiac Anesthesia, G.S Medical College, Mumbai, India.

Pushkar Desai
Department of Cardiac Anesthesia, G.S Medical College, Mumbai, India.

Shantaram Pawaskar
Department of Cardiac Anesthesia, G.S Medical College, Mumbai, India.

Shubhra Sarkar
Loni Medical College, Maharashtra, India.


View Book:-  https://stm.bookpi.org/NFMMR-V7/article/view/3224
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