Skip to main content

Clinical Effects of Mixed Infection of Trypanosomes and Ancylostoma caninum in Dogs and Treatment with Diminazene and Mebendazole (Nigeria) | Chapter 01 | Current Trends in Medicine and Medical Research Vol. 3

Trypanosomos is is one of the major diseases ravaging animals in Nigeria especially within Nsukka area in Enugu State. All species of trypanosomes, with the exception of some strains of T. vivax which produce a hyper acute and acute infection, are characterized by high parasitaemia, pyrexia, severe anaemia and haemorrhages on the mucosal and serosal surfaces. The socio-economic importance of trypanosomosis and ancylostomosis in both humans and animal necessitated the investigation of the clinical signs of single and conjunct infection of both parasites in dogs. Sixteen dogs grouped into 4 of 4 members each were used in the study. GROUP I was uninfected dogs (control), GROUP II was infected  with Ancylostoma  caninum GROUP  III  was  infected  with Trypanosoma  brucei (T.  brucei), GROUP  IV  was  mixed  infections  of Trypanosoma  brucei  and  Ancylostoma  caninum (T.  brucei/A. caninum). Post  acclimatization, Ancylostoma  caninum infection  was  done  on  GPII  and  GPIV.  Two weeks  later Trypanosoma brucei infections was  done  on  GPIII  and superimposed  on  GPIV. Three weeks post trypanosome infection; GPIII and GPIV were treated with 7 mg/kg diminazene aceturate (Veribin®, CEVA Sante Animale- La Ballasteiére 33501 Libourne Cedex, France) x intramuscularly x once. Mebendazole (Vermin®, Janssen-Cilag Ltd 50 -100 Holmers Farm Way, High Wycombe, Bucks, HP12 4EG UK)  at 100 mg x per  os twice daily for 3 days was used only on GPII and GPIV and a repeat treatment given 2 weeks later. Prepatent period of T.  brucei infection was 5.00±1.30 days in single  infection  and  3.00±1.40  days  in  conjunct  infection  of T.  brucei and A.  caninum. Persistent parasitaemia resulted in repeated treatment with diminazene aceturate at 7 mg/kg and mebendazole at  100  mg  twice  daily  for  3  days. The  predominant  signs  revealed  include;  fluctuation  in  weight, lethargy,  vomition,  enlargement  of  popliteal lymphnodes,  pyrexia,  oedema  of  lower  jaw  and  ocular discharges,  enlarged  abdomen,  anaemia,  cornea  opacity  and  slight  emaciation.  The  clinical  signs were  most  severe  in  GPIV  compared  to  GPIII.  The  egg  per  gram  of  faeces  (EPG)  in  GPII  was significantly  higher  than  the  mixed  infection  (GPIV).  Treatment  only  slightly  improved  clinical manifestations. In  conclusion,  most  signs  shown  were  consistent  with  trypanosomosis  in  dogs  except  abdominal enlargement  which  is  a  complication  of A.  caninum.  Clinical  signs  therefore  could  serve  as  a diagnostic tool in the treatment of both conditions in dogs. The severity of the disease conditions was more  in  the  conjunct group  compared  to  the  single  infection.  Treatment  of  the  diseases  with diminazene aceturate and mebendazole caused slight improvement in the clinical condition due to the resistant strain of T. brucei used in the study.

Author(s) Details

Dr. Rosemary I. O. Nwoha
Department of Veterinary Medicine, Micheal Okpara University of Agriculture, Umudike,  P.O.Box 824, Nigeria.

View Volume: https://doi.org/10.9734/bpi/ctmmr/v3

Comments

Popular posts from this blog

Empowerment and Leader Member Exchange towards Organizational Citizenship Behavior Readiness among Government Workforce in Malaysia | Book Publisher International

  State agencies are among the most significant entities that represent the public's needs, and their programmes are essential to a state's and the nation's economic growth and development. State agencies have been rife by public concerns for years, as demonstrated by the Public Complaints Bureau, as problems of inefficiency in service quality and delivery have yet to meet the public's standards. With the support of 15 employees from state agencies on Malaysia's east coast, this study aims to achieve three targets. The first and second objectives are to investigate the ties between leader-member exchange (LMX) and OCB empowerment. The final aim is to define the most significant factors that affect OCB willingness. A total of 288 people took part in the survey, which was conducted using a cluster sampling process. The survey items had achieved the necessary reliability, according to the pilot test results, and some sub-dimensions were renamed after factor analysis.

Re-asserting Cultural Perspectives: Old People and New Ideas in Bole Butake’s Lake God and The Survivors and Sankie Maimo’s Succession in Sarkov | Chapter 10 | Perspectives of Arts and Social Studies Vol. 2

African cultures have undergone transformations from the colonial period to the present, often to the detriment of its cultural evolution and within the larger global community. As it were, colonial education subordinated African communalism and created in its place an anti-African spirit evident in the assimilation of western values. This did not only end up in a kind of cultural betrayal, but also posed as a serious threat to the dignity and identity of the people. Those who fall prey to this kind of cultural imperialism are the young people who are often irrationally carried away by western fashion and modes that they tend to neglect and/or forget their cultural ways of life as they join the race of “progress.” This situation has given rise to a conscious effort by creative writers to re-assert and protect African values while at the same time liberating themselves from the longstanding western effort at suppressing, controlling and dominating their thoughts particularly through n

The Utilization of Agro-Waste: A Nanobiotechnology Point of View | Chapter 10 | Recent Advances in Biological Research Vol. 5

Aims: To review the utilization of agro-waste in the eco-friendly synthesis of nanoparticles and their biomedical, catalytic and industrial applications. Study Design: A review. Place and Duration of Study: This review was carried out in the interim of three weeks exploiting all relevant data, literature and publications where necessary. Methodology: Profound gathering of literatures/publications and reviews were employed with all carefulness and professional courtesy; enough useful information were gathered over time. The introduction emphasizes the dawn of science and technology, when great ideas were still latent later leading to the advent of history changing innovations like the completion of human genome and then the birth of nanotechnology. Although, nanotechnology had been known decades been popularized by Richard Feynman in his talks in the year 1959; and in this present dispensation, nanotechnology has been a solution to many intricate challenges/ t