Contribution of Three (3) Medicinal Plants of Senegalese Flora in the Management of Sickle Cell Disease | Chapter 07 | Advances in Applied Science and Technology Vol. 4
Sickle cell disease is a major public
health problem in Africa and many other areas across the world. Many drugs
that are available
for treating the
disease are insufficiently effective,
toxic, or too expensive. Therefore, there is a pressing
need for safe, effective, and inexpensive therapeutic agents from indigenous
plants used in
traditional medicines. In
Senegal, a lot
of plants are
proposed by traditional healers
to manage the sickle cell disease, among them Combretum glutinosum, Leptadenia
hastate and Maytenus senegalensis. These
plants were studied in this work. Methanolic and ethyl acetate extracts of part
of these plants were evaluated on SS sickles type to determine their
anti-sickling potential. Antiradical properties of methanolic extract of C
glutinosum were evaluated using the
DPPH radical as oxidant.
Total phenolic content
of the methanol
extract was determined. Phytochemical screening of the
crude extract of methanol revealed the presence of tannins, saponins, phenols,
anthracenics and flavonoids. Results show a good antisickling effect of
methanol extracts with a maximum antisickling revers of 72, 80 and 81% for
respectively M senegalensis, L hastateand C glutinosumat 10 mg/mL in 120 min
incubation while ethyl acetate extract at the same conditions has 62, 66 and
77% of sickling reverse. Arginine used as the positive reference has 67%
sickling reverse activity at 120 min of incubation. The measured IC50 were 0.65
and 0.163 for respectively the methanol
extract and ascorbic
acid. Antiradical powers
0.155 and 0.62
respectively for methanol extract and ascorbic acid were
calculated from the effective concentrations. The results of this study confirm
the traditional use these three plants in the management of sickle cell disease.
Author(s) Details
Pr. Cheikh Sall
Laboratory of Chemistry,
Training and Research Unit of Health, Thies University, PB 967 Thies, Sénégal.
Pr Matar Seck
Laboratory of Organic and
Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.),
Cheikh Anta Diop University (U.C.A.D.), PB 5005 Dakar-Fann, Sénégal.
Rokhaya Sylla Gueye
Laboratory of Organic and
Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.),
Cheikh Anta Diop University (U.C.A.D.), PB 5005 Dakar-Fann, Sénégal.
Tandakha Ndiaye Dieye
Laboratory of Immunology,
Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University (U.C.A.D.),
Sénégal.
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