Copper Nanomaterials as Delivery System in Combating Infective Agents and Cancer | Chapter 10 | Recent Advances in Biological Research Vol. 2
Infectious diseases portend serious
threat hazards to public health globally due to the development of the resistance
to broad spectrum antimicrobials, the emergence of multidrug resistant
biofilms, the drug side-toxicity, the non-specificity of drug targeting and the
inability to overcome biological barriers. In this context,
nanotechnology-based metal nanoparticles have attracted attention as
nanomedicine against different diseases for their additional capability to
anchore other therapeutic contents effectively for delivery. Owing to the large
surface area to volume ratio, copper nanomaterials have been utilized as
potential anti-infective and anticarcinogenic agent in biomedical applications.
Though their higher significant efficiencies in damaging pathogenic cells have
been elucidated, their nano-metallic toxicity increases other side-toxicity to
healthy cells. Therefore, copper, copper oxide and copper sulfide
-nanoparticles should be surface functionalized with ligands and vesicular
system to reduce the toxic side effect for delivering to specific site of
interest in a sustained-release manner. The subject has been focused mainly on
the synthesis, size and surface characteristics, mechanism of action and
biomedical applications of copper nanomaterials in damaging various infective
agents and cancer cells as probable potent drug delivery system.
Biography of author(s)
Ardhendu Kumar Mandal
Central Instrumentation
Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road,
Jadavpur, Kolkata – 700032, India
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