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Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats | Chapter: 4 | Modern Advances in Pharmaceutical Research Vol. 1

Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory  and  immune  modulatory  constituents,  can  modify  and  prevent  the  detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citrates decoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C.  citrates decoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats.

Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): The control (group 1, G1), GV alone (G2), GV plus C. citratusdecoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6).
Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days.

Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures.

Results: The results showed that GV significantly (p < 0.05) decreased serum levels of P3, E2, LH, FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However,  co-administration of C.  citrates at different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p < 0.05) increased the levels of the GV-reduced  reproductive  hormones  and  antioxidant  enzyme  and  decreased  the  GV-increased oxidative stress marker levels to levels similar to those in the control group.

Conclusion: Thus, C.  citrates decoction  has  an  ameliorative  effect  on  GV-induced  reproductive dysfunction and oxidative stress.

Biography of author(s)

Christopher E. Ekpenyong
Department of Physiology, University of Uyo, Uyo, Nigeria

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