Immunity and Sex Concerns on Behaviour From IgE vs IgG to sex conditioned socialization? | Chapter 10 | Modern Advances in Pharmaceutical Research Vol. 1

Aims: To find evidence that the immune response modifies behavior by regulating sex hormones.

Study Design: Experimental transversal case control study and longitudinal experimental case control study.

Place and Duration of Study: Biochemistry and Molecular Biology Chair, School of Medicine, Medical Sciences Faculty, National University of Córdoba. 2009-2015.

Methodology: Albino Swiss mice Rockefeller strain (110) weighing 30g were assigned to two experimental designs. Transversal case control physiologic solution vs or Celtis tala pollen glycoprotein T or Bovine serum albumin A evaluated in forced swimming test along the course of antibodies production. Similar study but cases were treated with spironolactone (S) and immunized as previous mice. Longitudinal case control study with cases and controls the same categories as the second study but followed and evaluated in FST. Climbing, swimming floating summing a total of 8 events and delated time to contact another mouse (CT) were recorded (seconds). Plasma IgE, IgG and testosterone (Tt) were also measured.

Results: Immunization with T increases the proportion of climbing in both sexes at day 7(C male 0.42, T male 0.72, C female 0.28, T female 0.68) and reverted at day 15 (C male 0.8, T male 0.35, C female 0.47, T female 0.43), while A increased swimming in both sexes. Since climbing is more frequent in male we treated mice with S to determine if immunization effects were mediated by testosterone and reverted the changes triggered by C. tala (day 7, ST. males 0.22, ST females 0.35, day 15 ST. male 0.23, ST. female 0.32). T caused a shortening of CT in males from day 7 to 15, S produced the opposite and ST was partly similar to T (T.male12.5 to 5, S male 8,2 to 14, ST male 11 to 4.2 in sec, T female 2.9 to 6.2, S female 7.8 to 17, ST female 13 to 9.6 sec). SA in males enhanced swimming and decreased floating while in female decreased swimming and increased floating. Plasma concentration ranges of Tt (ng/mL) were: CM 0.75-6.72, TM 31.1-58.5; STM 26-29.5; females remained between 0.3-039, AM 0.75-9, AF 1-19, SAM 26.5-29, SAF 0.9-1.2.

Conclusion: The results presented in this paper support our hypothesis that immune response could modify mice FST performance and socialization post stress by regulation of testosterone levels.

Author(s) Details

SadíCossy Isasi
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.

Christian Jalil
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.

Guillermo Nicolás Giordano and Jimena Ortiz,
Catedra de Bioquimica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.

Prof Julio Cesar Cosiansi Bai
Cátedra de Medicina II, UNAPA Hospital Ntra. Sra. de la Misericordia, Argentina.

Juan CarlosMuiño MD
Centro Formador de la Especialidad en Alergia e Inmunología/Centro Formador Asociación Asma Alergia e Inmunología de Córdoba, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Belgrano 1502 Córdoba, Argentina.

Read full article: http://bp.bookpi.org/index.php/bpi/catalog/view/47/238/403-1

View Volume: https://doi.org/10.9734/bpi/mapr/v1

A Prospective Study about Safety and Efficacy of Perioperative Lidocaine Infusion | Chapter 09 | New Horizons in Medicine and Medical Research Vol. 8

Opioids cause clinically significant side effects such as respiratory depression, immunosuppression, muscle rigidity, negative inotropism, nausea, vomiting, hyperalgesia, urine retention, postoperative ileus, and drowsiness. Perioperative opioids are a major contributor to the United States' and other countries' opioid epidemics. Non-opioid analgesics, particularly lidocaine, are becoming more common for perioperative use as a result of this. A total of 185 adult patients were randomly assigned to one of two groups: control group I (105 patients) [fentanyl group] or group ii (80 patients) [opioid-free anaesthesia group]. Lidocaine 1.5 mg/kg bolus followed by 1.5 mg/kg/h infusion intraoperatively, and 1.5-2 mg/kg/h infusion for 2-8 hours postoperatively were given to patients in both groups at anaesthetic induction. Intraoperatively, both groups received analgesic adjuvants such as diclofenac 75 mg, paracetamol 1 gm, and mgso4 30-50 mg/kg. If the mean arterial pressure (map)

A Brief Study of Middleware Technologies: Programming Applications and Management Systems | Chapter 15 | Novel Research Aspects in Mathematical and Computer Science Vol. 1

Many platforms, services, applications, hardware, and operating systems are connected through the middleware layer. Because the middleware layer abstracts much low-level complexity and makes applications and software systems portable, it allows disparate systems to interface and function together in harmony. Middleware technologies enable software engineers to swiftly construct software systems and applications, allowing developers to focus on more important tasks. This chapter examines several types of middleware systems and discusses middleware capabilities, middleware operation, middleware's function in cloud-based systems, and the best middleware platforms to use. Middleware systems are widely utilised and can be found in practically any software system or application. Middleware programmes provide as a link between many sorts of systems and protocols. They serve as a mechanism for various systems. To successfully exchange information, it runs on a variety of operating system

Patients’ Perspective of Acute Post-operative Pain Management: A Multicentre Survey of Tertiary Hospitals in Maharashtra, India | Chapter 08 | New Horizons in Medicine and Medical Research Vol. 8

When postoperative pain is adequately controlled, patients' satisfaction and patient-related outcomes (PROs) increase. Understanding the patients' perspective is crucial since it supports in the formulation of improvement strategies. Because wrong attitudes and assumptions might block pain alleviation, patients' attitudes and beliefs are critical. As a result, a multicenter study of patients' attitudes, beliefs, experiences, and satisfaction levels with acute postoperative pain management was done in Maharashtra's tertiary hospitals. In addition, the responses were examined to evaluate if the Acute Pain Service (APS) resulted in improved patient outcomes and satisfaction. A 13-item questionnaire adapted from previous studies was used to capture patients' experiences with postoperative pain treatment. The responses of 179 patients are included in the study. The findings revealed that 91.6 percent of patients experienced postoperative pain, with 75.5 percent

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