Immunity and Sex Concerns on Behaviour From IgE vs IgG to sex conditioned socialization? | Chapter 10 | Modern Advances in Pharmaceutical Research Vol. 1
Aims: To find evidence
that the immune response modifies behavior by regulating sex hormones.
Study Design: Experimental
transversal case control study and longitudinal experimental case control
study.
Place and Duration of Study:
Biochemistry and Molecular Biology Chair, School of Medicine, Medical Sciences
Faculty, National University of Córdoba. 2009-2015.
Methodology: Albino Swiss
mice Rockefeller strain (110) weighing 30g were assigned to two experimental designs.
Transversal case control physiologic solution vs or Celtis tala pollen
glycoprotein T or Bovine serum albumin A evaluated in forced swimming test
along the course of antibodies production. Similar study but cases were treated
with spironolactone (S) and immunized as previous mice. Longitudinal case
control study with cases and controls the same categories as the second study
but followed and evaluated in FST. Climbing, swimming floating summing a total
of 8 events and delated time to contact another mouse (CT) were recorded (seconds).
Plasma IgE, IgG and testosterone (Tt) were also measured.
Results: Immunization
with T increases the proportion of climbing in both sexes at day 7(C male 0.42,
T male 0.72, C female 0.28, T female 0.68) and reverted at day 15 (C male 0.8,
T male 0.35, C female 0.47, T female 0.43), while A increased swimming in both
sexes. Since climbing is more frequent in male we treated mice with S to
determine if immunization effects were mediated by testosterone and reverted
the changes triggered by C. tala (day 7, ST. males 0.22, ST females 0.35, day 15
ST. male 0.23, ST. female 0.32). T caused a shortening of CT in males from day
7 to 15, S produced the opposite and ST was partly similar to T (T.male12.5 to
5, S male 8,2 to 14, ST male 11 to 4.2 in sec, T female 2.9 to 6.2, S female
7.8 to 17, ST female 13 to 9.6 sec). SA in males enhanced swimming and
decreased floating while
in female decreased swimming
and increased floating.
Plasma concentration ranges of Tt (ng/mL) were: CM 0.75-6.72, TM
31.1-58.5; STM 26-29.5; females remained between 0.3-039, AM 0.75-9, AF 1-19,
SAM 26.5-29, SAF 0.9-1.2.
Conclusion: The results
presented in this paper support our hypothesis that immune response could
modify mice FST performance and socialization post stress by regulation of
testosterone levels.
Author(s) Details
SadíCossy Isasi
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Christian Jalil
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Guillermo Nicolás Giordano and Jimena Ortiz,
Catedra de Bioquimica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Catedra de Bioquimica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Prof Julio Cesar Cosiansi Bai
Cátedra de Medicina II, UNAPA Hospital Ntra. Sra. de la Misericordia, Argentina.
Cátedra de Medicina II, UNAPA Hospital Ntra. Sra. de la Misericordia, Argentina.
Juan CarlosMuiño MD
Centro Formador de la Especialidad en Alergia e Inmunología/Centro Formador Asociación Asma Alergia e Inmunología de Córdoba, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Belgrano 1502 Córdoba, Argentina.
Centro Formador de la Especialidad en Alergia e Inmunología/Centro Formador Asociación Asma Alergia e Inmunología de Córdoba, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Belgrano 1502 Córdoba, Argentina.
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