Low Dose Aspirin and Omega 3 Fatty Acids in the Pro Resolving Pathway of Cardiovascular Disorders | Chapter 14 | Current Trends in Medicine and Medical Research Vol. 3
Newer mechanisms of action of Acetyl
Salicylic acid have been discovered in proresolving pathway of various
disorders. Omega 3 fatty acids are also involved in the synthesis of resolvins
via an aspirin triggered pathway. The
present review aims
to discuss the
role of recently
discovered aspirin triggered
lipoxins, resolvins, protectins, maresins in understanding the pathophysiology
of endothelial dysfunction in various
cardiovascular disorders, especially
hypertension. The concept
of aspirin triggered lipoxins
(15-epi-LXA4 and 15-epi-LX4)counteracting the action of
LTB4.PGE2, and TXA2 is discussed. Aspirin
triggered lipoxins also block the expression of IL-8 gene. Aspirin is the only
known NSAID to induce NO in a dose dependent manner. In this chapter, we
describe role of acetyl salicylic acid in the pro-resolution pathways that
might prevent or reduce complications in patients with high blood pressure.
Aspirin is a low cost intervention that can prevent the atherosclerosis of
vessels by its anti-inflammatory, antiplatelet and proresolving abilities.
Recent understanding of the pathophysiology of
hypertension and proresolving
pathways can help
to understand the
rational use of
aspirin in prevention and
reducing the complications
of high blood
pressure. A combination
of aspirin and omega 3 fatty acids has potential
benefits. DHA metabolites have been found to have potent role in the resolution
pathway of inflammation. Future endeavors would focus on the identification of
subset of high-risk hypertensive patients who will benefit most from aspirin,
omega 3 fatty acids and DHA. Different
dosage and time
of initiation in
various high-risk groups
needs to be
identified. Further research is
also required to identify the correct time and the oral doses that will help in
minimizing the long-term risk of future cardiovascular diseases.
Author(s) Details
Dr. Jayavelan Ramkumar
Department of Cardiothoracic
Surgery, Sri Ramachandra Medical College and University, Chennai-600116, India.
Dr. Nidhi Sharma
Department of Obstetrics and
Gynaecology, Saveetha Medical College, Saveetha University,
Chennai-602105,India.
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