Metabolic Syndrome in Postmenopause: eNOS, p22 phox, CETP and ESR1 Gene Polymorphisms Related to Endocrine-Metabolic Changes | Chapter 09 | New Insights into Disease and Pathogen Research Vol. 1
Aims:
To investigate the endocrine-metabolic changes in postmenopausal women with
MetS and examine relationship with the polymorphisms of eNOS-G894T,
p22(phox)-930 A/G, CETP TaqIB, ESR1 (PvuII and XbaI) genes.
Methods:
280 postmenopausal apparently healthy women aged between 60 and 80 years were
classified into non-MetS (212) and MetS (68). Clinical, anthropometric and
endocrine-metabolic parameters were measured. The single nucleotide
polymorphisms were determined and tested for interacting with these parameters.
Results:
The weight, waist circumference, blood pressure, WBC, triglycerides, LDL-C,
TG/HDL-C ratio, apolipoprotein (apo)B, apoB/apoA-I ratio, fasting glucose,
insulin, HOMA, uric acid, were higher
and HDL-C was lower in MetS group thus
fulfilled the criteria for the MetS. The significant higher levels of
E2, T3, GHBP, PTH and lower levels of cortisol, SHBG, FSH, LH, IGFBP1,
cortisol/DHEA ratio were also detected.
Genetic association studies showed that
presence of A allele p22phoxA/G (OR=1.62; CI=1.08-2.42) and heterozygote
AG-XbaI(ESR1) (OR=2.29; CI= 1.19-4.37) indicated a significant risk for MetS.
The binary logistic regression (MetS vs Controls) showed an interaction of
G894TeNOS polymorphism with MetS (OR>2.5; 95% CI =1.47-4.90) that associated
with SBP, TG, apoB, uric acid, ASTGOT (OR>1) and HDL-C (OR<1). CETP TaqIB
polymorphism associated with MetS (OR<1) in presence of SBP, GLU, TG with
OR>1. ESR1 PvuII (T/C) associated with MetS (OR between 1.59-8.60) in
presence of LDL-C, TG/HDL-C ratio, P with OD>1 and HDL-C, androstenedione,
SHBG, FAI with OR<1.
In MetS group the carriers of -TT
(eNOS-G894T) genotype had higher levels of blood pressure, glucose; -GG
(p22phox A/G) had higher levels of BMI, apoB/apoA ratio; -B1B2 (CETP B1/B2) had
higher levels of SBP, glucose, cholesterol, HDL-C, CRP, GHBP and lower levels
of TSH; -CC (PvuII) and GG (XbaI) ESR1 genotypes showed higher levels of
glucose.
Conclusions:
These results sustain an interaction between the studied polymorphisms and the
endocrine-metabolic changes in MetS pathogenesis. Our results sustain an
interaction between the studied polymorphisms and their phenotypes in
conferring a higher susceptibility to the endocrine-metabolic changes involved
in pathogenesis of MetS. The elevated values of TG/HDL-C and apoB/apoA ratios
could be risk indicators for calculation cardiovascular risk in of MetS.
Author(s) Details
Olga Ianas
“C.I. Parhon” National
Institute of Endocrinology, Bd. Aviatorilor 34-38, S1, 011863, Bucharest,
Romania.
Dana Manda
“C.I. Parhon” National
Institute of Endocrinology, Bd. Aviatorilor 34-38, S1, 011863, Bucharest,
Romania.
Sabina Oros
“C.I. Parhon” National
Institute of Endocrinology, Bd. Aviatorilor 34-38, S1, 011863, Bucharest,
Romania.
“Carol Davila” University of
Medicine and Farmacy, Str. Dionisie Lupu 37, S2, 020021, Bucharest, Romania.
Oana Popa
“C.I. Parhon” National
Institute of Endocrinology, Bd. Aviatorilor 34-38, S1, 011863, Bucharest,
Romania.
Anca Sima
“Nicolae Simionescu”
Institute of Cellular Biology and Pathology, Str. B.P. Hasdeu 8, S5, 050568,
Bucharest, Romania.
View Volume: https://doi.org/10.9734/bpi/nidpr/v1
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