The Morphological Basis and Laws of Autopsy Interpretation: Exploring the Relationship between the Basic Medical Sciences, Anatomical Pathology and Clinical Practice | Chapter 08 | Current Trends in Medicine and Medical Research Vol. 4
The
discipline of Morbid
Anatomy or Anatomical
Pathology is a
bridge between the
basic medical sciences and
the clinical sciences [1]. It is
clinico-pathologic
discipline which deals
with the identification of
lesions, interpreting them correctly at
the macroscopic and
microscopic levels and relating them appropriately to known
diseases within the context of the index patient[2].Lesions are the structural
alterations seen in tissues as a result of the assault of the injurious agent
or pathological process. Thus, anatomical pathology establishes the basis for
the ‘dis ease’ or discomfort in patients. The human cell is known to be the
most basic unit of life and the tissue is constituted by cells having related
functions. Injurious agents affect cell structure and ultimately the physiology
and therefore the cell is the natural habitat of the disease processes.
Histopathology seeks to interpret the changes in the cell to define the
aetiology, evolution and progression of disease. An afflicted cell continues to perform its
functions at various
degrees of capability
as it finds
itself able to
adapt to negative situations and
maintain homeostasis. Each cell’s preserved structure guarantees preserved
biochemical constitution and therefore its routine physiological functions. A
compromise in structure without resolution or failure of homeostasis
automatically leads to poor biochemistry of the cells and poor functioning.
Tissues with related or complementary functions constitute organs and organs
with related functions and
contributory physiological relationships
constitute organ systems
which essentially make up the
whole human being. The relationship between anatomy, biochemistry and
physiology is interminable and inseparable though disease causing agents
violate this union.
Author(s) Details
Akinwumi O. Komolafe
Department of Morbid Anatomy
and Forensic Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
and Department of Morbid Anatomy and
Forensic Medicine, Obafemi Awolowo University Teaching Hospitals
Complex, Ile-Ife, Osun State, Nigeria.
View Volume: https://doi.org/10.9734/bpi/ctmmr/v4
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