The Morphological Basis and Laws of Autopsy Interpretation: Exploring the Relationship between the Basic Medical Sciences, Anatomical Pathology and Clinical Practice | Chapter 08 | Current Trends in Medicine and Medical Research Vol. 4
The discipline of Morbid Anatomy or Anatomical Pathology is a bridge between the basic medical sciences and the clinical sciences . It is clinico-pathologic discipline which deals with the identification of lesions, interpreting them correctly at the macroscopic and microscopic levels and relating them appropriately to known diseases within the context of the index patient.Lesions are the structural alterations seen in tissues as a result of the assault of the injurious agent or pathological process. Thus, anatomical pathology establishes the basis for the ‘dis ease’ or discomfort in patients. The human cell is known to be the most basic unit of life and the tissue is constituted by cells having related functions. Injurious agents affect cell structure and ultimately the physiology and therefore the cell is the natural habitat of the disease processes. Histopathology seeks to interpret the changes in the cell to define the aetiology, evolution and progression of disease. An afflicted cell continues to perform its functions at various degrees of capability as it finds itself able to adapt to negative situations and maintain homeostasis. Each cell’s preserved structure guarantees preserved biochemical constitution and therefore its routine physiological functions. A compromise in structure without resolution or failure of homeostasis automatically leads to poor biochemistry of the cells and poor functioning. Tissues with related or complementary functions constitute organs and organs with related functions and contributory physiological relationships constitute organ systems which essentially make up the whole human being. The relationship between anatomy, biochemistry and physiology is interminable and inseparable though disease causing agents violate this union.
Akinwumi O. Komolafe
Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria and Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
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