Skip to main content

Phytochemical and Antiepileptic Activity of the Ethanol Leaf Extracts of Culcasia falcifolia in Pentylenetetrazole Induced Seizure in Mice | Chapter 05 | Recent Advances in Biological Research Vol. 4

Aim: To investigate the phytochemicals and the anticonvulsant activity of the ethanol leaf extract of Culcasia falcifolia used in the traditional medical treatment of epilepsy.

Methodology: The phytochemical screening was carried out using standard protocol while the anticonvulsant activity was studied using Pentylenetetrazole in mice.

Result: The preliminary phytochemical screening carried out on the ethanol extract of Culcasia falcifolia revealed the presence of alkaloids, flavonoids, saponins, tannins, polyphenols, and glycosides. In the anticonvulsant activity, there was a significant (*p< 0.05, **p<0.01) increase in the mean latency of tonic convulsion (243.72 ± 6.90*, 402.56 ± 5.52**) and significant (*p< 0.05, **p<0.01) decrease in the mean duration of tonic convulsion (192.62 ± 7.72*, 158.99 ± 8.66**) in a dose-dependent manner at the dose of 200 and 400 mg/kg body wt. respectively. The extract at 400 mg/kg body wt. showed 100% protection against mortality.



Conclusion: The results of this study suggest that the ethanol leaf extract of Culcasia falcifolia possesses anticonvulsant activity in PTZ induced seizure in mice. Therefore, the findings of the present study, suggests that ethanol extract of Culcasia falcifolia leaves has anticonvulsant activity against PTZ-induced seizures in mice by modulating GABA receptor-mediated inhibitory neurotransmission, reducing the T-type of Ca++ currents, activating GABAA receptors and facilitating the GABA-mediated opening of Chloride channel. Based on the folkloric claims, we infer that the decoction of the leaves of Culcasia falcifolia could be integrated into health care system for the management of epilepsy.

Author(s) Details

A. Gracelyn Portia
Department of Biological Sciences, University of Eastern Africa, Baraton, P.O.Box – 2500, Eldoret – 30100, Kenya.

D. M. Mwaniki
Department of Biological Sciences, University of Eldoret, P.O.Box 1125-30100 Eldoret, Kenya.

A. G. M. Ng’wena
Department of Medical Physiology, Maseno University, Maseno – 40105, Kenya.

Comments

Popular posts from this blog

Consensus Summit: Lipids and Cardiovascular Health in the Nigerian Population | Chapter 09 | Current Trends in Food Science Vol. 1

Aims: To issue a consensus statement on Lipids and Cardiovascular Health and the impact of their interrelationship in Nigerian Population. Study Design: Experts from a range of relevant disciplines, deliberated on different aspects of Lipids and Cardiovascular Health in the Nigerian Population at a Summit. Place and Duration of Study: The Summit was held in April 2016 at the Nigerian Institute of Medical Research. Methodology: Presentations were made on central themes after which expert participants split into four different groups to consider the questions relevant to different sub themes of the title. Consensus was arrived at, from presentations of groups at plenary. Conclusion: With the increase in the prevalence of NCDs, especially Cardiovascular Disease in Nigeria, and the documented evidence of deleterious effects of lipids, the expert panel called for an urgent need to advocate for the general public and health professionals to make heart-friendly

A Review on Gongronema latifolium, an Extremely Useful Plant with Great Prospects | Chapter 11 | Recent Advances in Biological Research Vol. 3

Gongronema latifolium is a plant that has a wide range of nutritional and ethnomedical uses in different tropical African communities. Scientific reports on the chemical composition and bioactivity (anti-inflammatory, antimicrobial, antidiabetic, antioxidant, anticancer and allelopathic properties) of the plant material by different authors are discussed in this review. Future prospects of the plant extracts in the areas of herbal formulations, food preservation, alcoholic fermentation and beer production, drug discovery and allelopathy are also highlighted. Author   Details: Olugbenga Morebise Faculty of Basic Medical Sciences, All Saints University School of Medicine, Roseau, Commonwealth of Dominica. Read full article: http://bp.bookpi.org/index.php/bpi/catalog/view/50/403/433-1 View Volume: https://doi.org/10.9734/bpi/rabr/v3

An Overview of Ultrasonic Technology and Its Applications in Food Processing, Preservation and Quality Control | Chapter 03 | Current Research in Science and Technology Vol. 3

Ultrasound is one of the emerging technologies that were developed to minimize processing, maximize quality and ensure the safety of food products. In recent years, ultrasound technology has been used as an alternative processing option to conventional thermal approaches. Although Ultrasonication methods have been used for years in research and diagnostics, major advances have been made in the last decade. The applications for which high power ultrasound can be used range from existing processes that are enhanced by the retrofitting of high power ultrasonic technology, to the development of processes up to now not possible with conventional energy sources. The present paper reviews the generation, principle mechanism, properties, process parameters, applications, merits and demerits and future trends of the ultrasound technology in the food processing. Author(s) Details Er. Bogala Madhu Department of Processing and Food Engineering, College of Technology and Engineering, MP