Alterations of Bronchial Cytokines in Bronchial Carcinoid Tumor Perioperatively | Chapter 06 | New Insights into Disease and Pathogen Research Vol. 2
As bronchial carcinoids are known to be
notably rare, adequate histochemical investigations couldn’t have been carried
out on these types of tumors hitherto. In this study, we investigated bronchial
cytokines in a carcinoid tumor localized in the left main bronchus. Bronchial
resection and reconstruction was performed without the lung resection. Bronchial
lavage samples were obtained from both sides of main bronchial system
preoperatively and postoperatively. TNF- α, IL- 8 and IL- 6 levels were
measured by ELİSA. Preoperative TNF- α and IL- 8 levels were found to be
2-folds and 5-folds higher on the tumor side respectively (TNF- α; 14.184 pg/ml
and IL- 8; 3359.86 pg/ml) compared to tumor-free bronchial system (TNF- α;
6.886 pg/ml, IL- 8; 615.072 pg/ml). Interestingly, both cytokine levels were
found to be equal and within normal ranges on both sides subsequent to
bronchial resection and reconstruction. There were no significant difference in
IL- 6 levels between two bronchial systems preoperatively (IL- 6 levels of
right bronchus, 16.44 pg/ml; levels of left bronchus, 19.11 pg/ml). However,
there was more than four-fold increase in postoperative levels (IL- 6 level;
89.41 pg/ml). In this chapter, we found that preoperative TNF- α and IL- 8
levels were higher compared to the postoperative ones; whereas IL- 6 levels
showed a significant increase, postoperatively. These findings led us through
the idea that carcinoid tumors might be activating the inflammatory process
among TNF- α and IL- 8 and the surgical bronchoplastic procedure could be the
cause of enhanced IL-6 response.
Author(s) Details
Nilgün Kanlıoğlu Kuman
Department of Thoracic
Surgery, Faculty of Medicine, Adnan Menderes University, Turkey.
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