Buddleja Species Distributed in Mexico against Inflammatory Diseases, Their Therapeutic Activities, Secondary Metabolites and Biotechnology | Chapter 08 | Recent Advances in Biological Research Vol. 5
B. americana, B.
cordata, B. parviflora, B. perfoliata, B. scordioides and B. sessiliflora,
belonging to Buddleja Genus, are species distributed in Mexico reported in folk
medicine to treat ills related to inflammatory processes. For some of them,
this ethnopharmacological uses have been validated by scientific studies. Their
phytochemistry has been related for their medicinal properties, being mainly
iridoids, flavonoids and phenylethanoids because all of them are secondary
metabolites credited with anti-inflammatory biological activity. Particularly,
in folk medicine, those plants showing high concentrations of verbascoside
secondary metabolite have been traditionally used to treat inflammation. In B.
cordata, a cell culture has been developed since plant cell and tissue culture
is a biotechnological tool that allows producing bioactive secondary
metabolites in high concentrations as an alternative and sustainable form
different to extraction from whole wild plants; meantime this protects wild
medicinal plants from excessive use and collects. This cell culture produced
verbascoside in a higher concentration than whole wild plant and the methanolic
extract obtained from the cells demonstrated to be a satisfying
anti-inflammatory agent on in vivo pre-clinical studies of acute and chronic
inflammation, due to it modulates the production of interleukins expressed
during an inflammatory process, lymphocytes tissue concentrations, decrease
oxidative stress and leukocyte infiltration. New scientific studies should be
done in those Buddleja species distributed in Mexico that have not credited its
anti-inflammatory ethnomedicinal effect as well as to start on developing works
to establish plant cell and tissue cultures. Moreover, new works should be
continued about biotechnological advances on B. cordata. The aim of this work
is to review the therapeutic activities, secondary metabolites and
biotechnology advances of Buddleja species distributed in Mexico used against
inflammatory diseases.
Author(s) Details
María Elena Estrada-Zúñiga
Centro de Investigación en
Recursos Bióticos, Facultad de Ciencias, Universidad Autónoma del Estado de
México, Carretera Toluca-Ixtlahuaca Km 14.5, San Cayetano CP 50295, Toluca,
Estado de México, México.
Gabriel Alfonso
Gutiérrez-Rebolledo
Departamento de
Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael
Atlixco No. 186, Col. Vicentina CP 09340, México D.F., México.
Aurelio Nieto-Trujillo
Departamento de
Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael
Atlixco No. 186, Col. Vicentina CP 09340, México D.F., México.
Dr. Antonio Bernabé-Antonio
Departamento de Madera,
Celulosa y Papel, Centro Universitario de Ciencias Exactas e Ingenierías,
Universidad de Guadalajara, Km. 15.5. Carretera Guadalajara-Nogales, Col. Las
Agujas, CP 45010, Zapopan, Jalisco, México.
Francisco Cruz Sosa
Departamento de
Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael
Atlixco No. 186, Col. Vicentina CP 09340, México D.F., México.
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