Mass Spectrometry Techniques ESI and MALDI in Characterization of Colchicine and Colchiceine Complexes | Chapter 02 | New Advances in Materials Science and Engineering Vol. 1
Complexes are biologically useful
compounds and they have many biological activities. Many different inorganic
and organic compounds can form stable complexes. Complexes of organic
compounds, in which ligands are biologically active part, for example
alkaloids, are especially interesting for researchers. Alkaloids: Colchicine and
colchiceine can form stable complexes with alkali metals. A series of complexes
of both alkaloids have been obtained and studied by ESI MS, MALDI MS, 1H
and 13C NMR, FT IR, DFT and PM5/PM7 calculations and molecular
modelling. These complexes also have been tested against fungicidal and
cytotoxic activity. The colchicine complexes with Li+, Na+,
K+ cations of different salts have been studied in details by MALDI
and ESI mass spectra. In the ESI MS mass spectra has been shown that colchicine
forms stable complexes of 1:1 stoichiometry with monovalent and divalent metal
cations. Also formation of complexes of various stoichiometry has been
detected. Colchicine complexes have not been characterised by modern mass
spectra methods such as MALDI MS. The aim of this study was to summarize ESI MS
study on colchicine and colchiceine complexes and check fragmentation pathways
of colchicine complexes with alkali metals by MALDI MS mass spectra.
Author(s) Details
Joanna Kurek
Faculty of Chemistry, A.
Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Grażyna Bartkowiak
Faculty of Chemistry, A.
Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
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