Skip to main content

Structure, Expression and Functions of Bovine Alpha-Tocopherol Transfer Protein (α-TTP) | Chapter 07 | Recent Advances in Biological Research Vol. 5

α-tocopherol transfer protein (α-TTP) of bovine consists of 282 amino acids with 98% and 83% identities to sheep and rat orthologs, respectively. Bovine α-TTP has an additional 5 amino acids (GEEVT) at the C terminus, which rat, human, mouse α-TTPs do not have. The Blast research suggested that the C-terminal sequences of α-TTP are specific for Cetartiodactyla animals. Bovine α-TTP mRNA and protein were expressed most strongly in liver, and also in lung, whereas expression of α-TTP mRNA and protein are reported to be very weak or absent in human and rodent lungs. In the lung, immunostaining suggested that α-TTP is expressed specifically in alveolar walls, which consists of alveolar cells, epithelial cells of small bronchi, and endothelial cells of pulmonary blood vessels. These results suggest that, in the lung, α-TTP is involved in supplying vitamin E to alveolar surfactant in order to protect the lung tissue from oxidative stress, and that this role may be more important in bovines than in other mammals.


Author(s) Details

Dr. Yoshitomo Taguchi
Department of Genetic Engineering, Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama 649-6493, Japan.

View Volume: https://doi.org/10.9734/bpi/rabr/v5

Comments

Popular posts from this blog

A Brief Study of Middleware Technologies: Programming Applications and Management Systems | Chapter 15 | Novel Research Aspects in Mathematical and Computer Science Vol. 1

  Many platforms, services, applications, hardware, and operating systems are connected through the middleware layer. Because the middleware layer abstracts much low-level complexity and makes applications and software systems portable, it allows disparate systems to interface and function together in harmony. Middleware technologies enable software engineers to swiftly construct software systems and applications, allowing developers to focus on more important tasks. This chapter examines several types of middleware systems and discusses middleware capabilities, middleware operation, middleware's function in cloud-based systems, and the best middleware platforms to use. Middleware systems are widely utilised and can be found in practically any software system or application. Middleware programmes provide as a link between many sorts of systems and protocols. They serve as a mechanism for various systems. To successfully exchange information, it runs on a variety of operating system

A Prospective Study about Safety and Efficacy of Perioperative Lidocaine Infusion | Chapter 09 | New Horizons in Medicine and Medical Research Vol. 8

 Opioids cause clinically significant side effects such as respiratory depression, immunosuppression, muscle rigidity, negative inotropism, nausea, vomiting, hyperalgesia, urine retention, postoperative ileus, and drowsiness. Perioperative opioids are a major contributor to the United States' and other countries' opioid epidemics. Non-opioid analgesics, particularly lidocaine, are becoming more common for perioperative use as a result of this. A total of 185 adult patients were randomly assigned to one of two groups: control group I (105 patients) [fentanyl group] or group ii (80 patients) [opioid-free anaesthesia group]. Lidocaine 1.5 mg/kg bolus followed by 1.5 mg/kg/h infusion intraoperatively, and 1.5-2 mg/kg/h infusion for 2-8 hours postoperatively were given to patients in both groups at anaesthetic induction. Intraoperatively, both groups received analgesic adjuvants such as diclofenac 75 mg, paracetamol 1 gm, and mgso4 30-50 mg/kg. If the mean arterial pressure (map)

Scientific values of ECA Ligation | Chapter 06 | New Horizons in Medicine and Medical Research Vol. 8

  Previously, carotid artery ligation was done as an emergency procedure to stop severe haemorrhages in the head and neck. Despite this, it was abandoned because to high patient mortality and morbidity. However, ECA ligation, a more selective branch of the carotid artery, has been popular for the same goal in recent decades due to the lack of or modest postsurgical problems compared to Transarterial embolization (TAE). However, a good surge seal pack, especially in the maxilla, is occasionally required to regulate both collateral circulation and backflow of blood from the internal carotid arteries distal to the carotid arteries (ICA). ECA ligation, on the other hand, might be a superior alternative for controlling life-threatening uncontrolled bleeding in this area. Author(S) Details Jachmen Sultana Department of Oral and Maxillofacial Surgery, Dhaka Dental College and Hospital, Bangladesh. Abul Bashar Department of Paediatrics, Comilla Medical College and Hospital, Bangladesh.