Skip to main content

Hepatorenal Protective Effects of Pomegranate (Punica granatum) Juice against Nicotine Induced Toxicity in Guinea Pigs | Chapter 02 | Advances and Trends in Biotechnology and Genetics Vol. 2

Background: Pomegranate juice possess a marked antioxidant capacity with a high content in tannins, phenols and flavonoids which can directly or indirectly reduce oxidative damage by preventing the excessive generation of free radicals.

Objectives: The present work aimed to evaluate the effectiveness of pomegranate (Punica granatum) juice as a natural source of antioxidants to minimize the harmful effects of nicotine induced hepatorenal toxicity in Guinea pigs.

Materials and Methods: In this study, twenty four adult male Guinea pigs were used for this study and divided into four groups. The first group was control group, the 2nd group was administered the pomegranate juice orally, the 3rd was the experimental and received intraperitoneal injection of nicotine (6 mg/kg body weight /day), the 4th one co-administered intraperitoneal injection of nicotine (6 mg/kg body weight /day) and pomegranate juice  orally for 8 weeks. Blood samples were obtained for assessment of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and γ- glutamyltransferase activities, total proteins, albumin, and globulin concentrations, albumin concentration/globulin concentration (A/G) ratio, urea, uric acid, creatinine, sodium ions, and potassium ions concentrations.

Results: In nicotine treated animals, the serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and γ- glutamyl transferase activities, urea, uric acid, creatinine, and potassium ions concentrations were significantly (p<0.05), increased as compared to the control group. On the other hand, serum total proteins, albumin, globulin, sodium ions concentrations, and A/G ratio of nicotine treated Guinea pigs were significantly (p<0.05) decreased as compared to the control Guinea pigs. Co-administration of pomegranate juice significantly improved all biochemical parameters.

Conclusion:  It can be concluded that, nicotine had adverse effects on liver and kidney functions parameters in the blood serum. Pomegranate juice administration showed a remarkable amelioration of these abnormalities in nicotine treated male Guinea pigs. It is recommended that the heavy smokers should be advised to take pomegranate juice as a rich source of antioxidant to prevent the hepatorenal toxicity of nicotine. Further studies are necessary to elucidate exact mechanism of hepatorenal protection and potential usefulness of pomegranate juice as a protective agent against nicotine induced hepatorenal toxicity in clinical trials.

Author(s) Details

Dr. Azab Elsayed Azab
Department of Physiology, Faculty of Medicine, Sabratha University, Sabratha, Libya.

Dr. Mohamed Omar Albasha
Department of Zoology, Faculty of Science, Alejelat, Zawia University, Libya.

View Volume:


Popular posts from this blog

Consensus Summit: Lipids and Cardiovascular Health in the Nigerian Population | Chapter 09 | Current Trends in Food Science Vol. 1

Aims: To issue a consensus statement on Lipids and Cardiovascular Health and the impact of their interrelationship in Nigerian Population. Study Design: Experts from a range of relevant disciplines, deliberated on different aspects of Lipids and Cardiovascular Health in the Nigerian Population at a Summit. Place and Duration of Study: The Summit was held in April 2016 at the Nigerian Institute of Medical Research. Methodology: Presentations were made on central themes after which expert participants split into four different groups to consider the questions relevant to different sub themes of the title. Consensus was arrived at, from presentations of groups at plenary. Conclusion: With the increase in the prevalence of NCDs, especially Cardiovascular Disease in Nigeria, and the documented evidence of deleterious effects of lipids, the expert panel called for an urgent need to advocate for the general public and health professionals to make heart-friendly

A Review on Gongronema latifolium, an Extremely Useful Plant with Great Prospects | Chapter 11 | Recent Advances in Biological Research Vol. 3

Gongronema latifolium is a plant that has a wide range of nutritional and ethnomedical uses in different tropical African communities. Scientific reports on the chemical composition and bioactivity (anti-inflammatory, antimicrobial, antidiabetic, antioxidant, anticancer and allelopathic properties) of the plant material by different authors are discussed in this review. Future prospects of the plant extracts in the areas of herbal formulations, food preservation, alcoholic fermentation and beer production, drug discovery and allelopathy are also highlighted. Author   Details: Olugbenga Morebise Faculty of Basic Medical Sciences, All Saints University School of Medicine, Roseau, Commonwealth of Dominica. Read full article: View Volume:

Dictionary of Medicinal Plants - Scientific Names, Family and Selected Vernacular (English, Sinhala, Sanskrit and Tamil) Names | Book Publisher International

Medicinal plants have been known for centuries and are highly valued all over the world as a rich source of therapeutic agents of medicinal plants for public health care in developing nations [65]. Even today, the WHO estimates that up to 80 percent of the world population still relies mainly on traditional remedies such as herbs for their primary health care [13]. Ahmed et al. mentioned that according to a survey conducted by W.H.O., traditional healers treat 65% patients in Sri Lanka and 80% in India [3]. According to the WHO, around 21,000 plant species have the potential for being used as medicinal plants. Different ethnic and different language speaking peoples are living in Asian countries. Plants are commonly known by their local names in every part of the world. These local names play a very important role in ethno-botanical study of a specific tribe or region. Local names given to plants by indigenous people in their local dialects often reflect a broad spectrum of inf