Skip to main content

Kerosene: A Study of Tissue Histology and Serum Vitamin and Heavy Metal Levels of Female Wistar Rats Chronically Exposed | Chapter 07 | Advances and Trends in Biotechnology and Genetics Vol. 2

Background: Kerosene a commonly available product used for a variety of purposes in many parts of Asia and Africa is sometimes sold in beverage bottles and jerry cans in both commercial and residential places due to inadequate number of filling stations. Therefore excessive exposure through both dermal and oral routes is common.

Objective:
This study was embarked upon to ascertain the impact of trace amount of kerosene on tissue histology as well as serum vitamin and heavy metal levels in female Wistar rats.

Methods:
Kerosene (0.4 mL/kg body weight) was administered to rats either through the oral or dermal route daily for a period of 30 days. The effects of kerosene administration on tissue histology; serum vitamin levels and serum concentrations of heavy metals were evaluated using hematoxylin- eosin staining technique; high performance liquid chromatography (HPLC); and atomic absorption spectrometry (AAS) respectively. Student’s t test and analysis of variance were used for statistical analysis of data. P <0.05 was considered significant.

Results:
Histopathologic presentation such as pulmonary congestion, severely stunted villi, congestion of coronary vessels, and diffuse spongiosis of the cerebral cortex were observed in kerosene administered groups while control group featured no visible lesion. Results of heavy metals revealed that although As, Al and Cd were not significantly different in kerosene exposed groups compared with control, Si was significantly lower (oral), and significantly higer (dermal) compared with control. In addition, using analysis of variance (ANOVA) all estimated vitamins (except pantothenic acid) were significantly different in kerosene exposed groups compared with control.

Conclusion:
The results of this study indicate that exposure to this product either through the oral or dermal route may be detrimental to health as it induced adverse alteration in vitamin and heavy metal levels as well as distorted tissue histo-architecture.

Author(s) Details

Ayobola A. Iyanda
Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Nigeria.

View Volume: https://doi.org/10.9734/bpi/atbg/v2

Comments

Popular posts from this blog

Empowerment and Leader Member Exchange towards Organizational Citizenship Behavior Readiness among Government Workforce in Malaysia | Book Publisher International

  State agencies are among the most significant entities that represent the public's needs, and their programmes are essential to a state's and the nation's economic growth and development. State agencies have been rife by public concerns for years, as demonstrated by the Public Complaints Bureau, as problems of inefficiency in service quality and delivery have yet to meet the public's standards. With the support of 15 employees from state agencies on Malaysia's east coast, this study aims to achieve three targets. The first and second objectives are to investigate the ties between leader-member exchange (LMX) and OCB empowerment. The final aim is to define the most significant factors that affect OCB willingness. A total of 288 people took part in the survey, which was conducted using a cluster sampling process. The survey items had achieved the necessary reliability, according to the pilot test results, and some sub-dimensions were renamed after factor analysis.

Re-asserting Cultural Perspectives: Old People and New Ideas in Bole Butake’s Lake God and The Survivors and Sankie Maimo’s Succession in Sarkov | Chapter 10 | Perspectives of Arts and Social Studies Vol. 2

African cultures have undergone transformations from the colonial period to the present, often to the detriment of its cultural evolution and within the larger global community. As it were, colonial education subordinated African communalism and created in its place an anti-African spirit evident in the assimilation of western values. This did not only end up in a kind of cultural betrayal, but also posed as a serious threat to the dignity and identity of the people. Those who fall prey to this kind of cultural imperialism are the young people who are often irrationally carried away by western fashion and modes that they tend to neglect and/or forget their cultural ways of life as they join the race of “progress.” This situation has given rise to a conscious effort by creative writers to re-assert and protect African values while at the same time liberating themselves from the longstanding western effort at suppressing, controlling and dominating their thoughts particularly through n

The Utilization of Agro-Waste: A Nanobiotechnology Point of View | Chapter 10 | Recent Advances in Biological Research Vol. 5

Aims: To review the utilization of agro-waste in the eco-friendly synthesis of nanoparticles and their biomedical, catalytic and industrial applications. Study Design: A review. Place and Duration of Study: This review was carried out in the interim of three weeks exploiting all relevant data, literature and publications where necessary. Methodology: Profound gathering of literatures/publications and reviews were employed with all carefulness and professional courtesy; enough useful information were gathered over time. The introduction emphasizes the dawn of science and technology, when great ideas were still latent later leading to the advent of history changing innovations like the completion of human genome and then the birth of nanotechnology. Although, nanotechnology had been known decades been popularized by Richard Feynman in his talks in the year 1959; and in this present dispensation, nanotechnology has been a solution to many intricate challenges/ t