When knowledge fails to provide answers
to important questions such as how to improve the bioavailability of vital
medications, “Imagination is more important than knowledge,” as Albert Einstein
once said. Ingenuity in the design of effective prodrugs has been lacking in
quantity and quality. The reasons behind the low quality of ingenuity could be
related to the fact that medicinal chemists have expertise in organic and
organometalic chemistry not in biochemistry and biology. On the other hand,
pharmaceutical chemists, biologists and biochemists do not have the expertise
to make sophisticated chemical devices. Therefore, in order for a prodrug
strategy to work, a team consisting of all this expertise is necessary.
Author(s) Details
Professor Rafik Karaman
Department of Bioorganic
Chemistry, Faculty of Pharmacy, Al-Quds University, P.O. Box 20002, Jerusalem,
Palestine and
Department of Sciences, University of
Basilicata, Viadell’Ateneo Lucano 10, 85100, Potenza, Italy.
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