Skip to main content

Haemostatic Disorders in Sickle Cell Disease Subjects in Nigeria: A Review of Literature | Chapter 02 | Emerging Research in Medical Sciences Vol. 2

Background: Sickle cell disease (SCD) is an autosomal recessive disorder that is characterised with chronic anaemia and painful crisis. SCD is associated with hypercoagulability or prothrombotic state that can predispose to thromboembolic complications with increasing morbidity and mortality.

Aim: This study aimed to show the various documented haemostatic disorders and possible thromboembolic complications among SCD subjects in Nigeria.

Methods: A comprehensive literature search was performed using the internet search engines linked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, Scopus, etc. Studies involving hemostatic disorders in Nigeria were thoroughly searched, and the references of such articles were also searched for any probable relevant information.

Findings and Conclusion: There is a paucity of information on this subject in Nigeria, and there are inconsistencies in the available studies.

Haemostatic disorders in sickle cell disease are conditions that are associated with increased mortality and morbidity. Further research on the level of natural anticoagulant is required to verify the correlation between haemostatic disorders and thromboembolic complications in SCD subjects in Nigeria

Author(s) Details

Dr. Kingsley Akaba (MBBch, FMCPath)
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

Dr. Marcus Inyama
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

Dr. Timothy Ekwere
Department of Haematology and Blood Transfusion, University of Uyo Teaching Hospital, Uyo, Nigeria.

Dr. Obinna Iheanacho
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

Dr. Ekpeyong Bassey
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

Ushie Godwin
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

Dr. Hogan Archibong
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

Efiok Efiok
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria.

View Books: http://bp.bookpi.org/index.php/bpi/catalog/book/92

Labels

Labels:

Comments

Post a Comment

Popular posts from this blog

Greening Regional Airports: A Vision for Carbon Neutral Infrastructure | Chapter 12 | Contemporary Perspective on Science, Technology and Research Vol. 3

 This study provides an overview of the energy demand of a regional airport, divided into individual time horizons. The electrification of aircraft systems raises the question of whether airports will be among the largest electricity consumers in our infrastructure in the future. Sustainability and especially emission reductions are significant challenges for airports that are currently being addressed. The Clean Sky 2 project GENESIS addresses the environmental sustainability of hybrid-electric 50-passenger aircraft systems in a life cycle perspective to support the development of a technology roadmap for the transition to sustainable and competitive electric aircraft systems. This article originates from the GENESIS research and describes various options for ground power supply at a regional airport. Potential solutions for airport infrastructure with a short (2030), medium (2040), and long (2050) time horizon are proposed. In addition to the environmental and conservation benefi...
Post a Comment
Read more

Occipital Dermal Sinus Tract Causing Craniospinal Infection: A Review | Chapter 13 | New Visions in Medicine and Medical Science Vol. 4

  Dermal sinus is a rare congenital condition characterized by a pathological tract connecting the skin to deeper tissues of the central nervous system, potentially leading to severe infectious complications. It arises from a failure in the separation of ectodermal layers during early gestation. Diagnosing dermal sinus tract in newborns requires a careful physical examination, focusing on midline dimples in the occipital region associated with cutaneous abnormalities like hairy nevus or hyperpigmentation. The presence of drainage, abnormal hair distribution, or localized swelling may indicate a sinus tract. Regular examination for dimples or sinuses is recommended for infants and children with recurrent meningitis or infections. Early detection is crucial to prevent severe complications like meningitis, with Staphylococcus aureus being a common causative organism. Neuroradiological studies, including computed tomography (CT) scan and magnetic resonance imaging (MRI), with histopath...
Post a Comment
Read more

Alkali Element Modification of Glucose Molecules as a Method to Dissolve Cancer Cells | Chapter 12 | New Visions in Medicine and Medical Science Vol. 4

  The present study highlights about alkali element modification of glucose molecules as a method to dissolve cancer cells. The central regulation of the mechanisms governing cell proliferation has little effect on cancer cells. Cancer cells are entirely independent of the central command and divide and proliferate on their own, making it challenging to activate their response mechanism. Precisely, this is the reason why they are at risk to the health of humans and/or any biological entities. Instead of trying to reconnect the central command of the growth control mechanism to cancer cells that are already out of the range, we present a method of using the cancer cell’s own irresponsive and uncontrolled growth mechanism to their disadvantage and destroy the cancer cells. We found that this is achievable in an atomic/molecular level study of the glucose molecule, which is the primary food source used for growth and energy generation by all cells in the body, including the cancer cel...
Post a Comment
Read more