Biological Studies of Newly Synthesized Benzo[d][1,2,3]triazole Derivatives | Chapter 06 | Theory and Applications of Chemistry Vol. 3
The study of heterocyclic systems
provides most fascinating field for exploration in view of variety of
interesting and intricate reactions, which lead to synthesis of unusual systems
having diversities in their skeletal pattern. In this context, various new
heterocycles and derivatives are synthesized with increased biological
activities and less toxicity. Benzo-fused azoles containing three heteroatoms,
specially, benzo[d][1,2,3]triazole, has received great attention, these days,
for their chemical and biological properties and many of them are used as
medicines for various diseases. Many researches have also shown that when
heterocyclic and aliphatic secondary amines are introduced in a variety of
heterocyclic compounds, the resulting compounds have been found to possess
enhanced biological activities. Therefore aim of our research was to hook
benzotriazole scaffold with these amines with a help of suitable linker in
thirst of obtaining the resulting synthesized molecules possessing high and
varied biological activities which can be useful to mankind in future. We have
synthesized N-aminoalkylated derivatives of benzo[d][1,2,3]triazole. All the
synthesized compounds were fully characterized on the basis of their detailed
spectral studies and were evaluated for their antimicrobial activities in
vitro.
Author(s) Details
Bharti Bhardwaj
Department of Chemistry,
University of Delhi, Delhi-110 007, India.
Sunita Bhagat
Department of Chemistry,
ARSD College, University of Delhi, India.
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