Association of Adiponectin and Leptin with Coronary Atherosclerosis Severity Indices in Metabolic Syndrome Patients | Chapter 07 | Emerging Research in Medical Sciences Vol. 3
Adipose tissue is considered as an
active endocrine organ that releases a large number of adipokines modulating
blood pressure, glucose and lipid metabolism, inflammation, and
atherosclerosis. Atherosclerosis has been found linked with various traditional
and novel risk actors. This chapter describe the updated review of published
literature and present research findings describing the linkage of extent and
severity of coronary atherosclerosis with two of the adipokines, adiponectin
and leptin, as novel risk factors in metabolic syndrome (MetS) patients. A
pilot, Case-control study was carried under Sadbhavna Medical and Heart
Institute, Patiala and, Department of Pharmaceutical Sciences and Drug
Research, Punjabi University, Patiala, between January to December 2013. MetS
patients (n=55) with age ≥18 years, undergoing angiography for diagnosis and/or
interventional treatment of atherosclerosis and 25 matched control subjects
were recruited. Evaluation of traditional and novel cardiovascular risk factors
(adipose-derived hormones) and their association with angiographic-derived
presence and degree of atherosclerosis indices (number of blocked vessels,
severity index, and extent index) was carried out. Low serum adiponectin and
high total cholesterol level were found as the independent predictors of
atherosclerosis for number of blocked vessels. For extent and severity index,
low adiponectin level was the only significant and independent predictor.
Leptin and adiponectin/leptin (A/L) ratio could not prove as significant
predictors (p≥0.05). Based on the results, it was concluded that Total
cholesterol, adiponectin, leptin and A/L ratio might play a vital pathogenic
role not only in the occurrence, but also in the severity, extent, number of
vessels blocked complexity in MetS.
Author(s) Details
Kanchan Vohra
Department of Pharmaceutical
Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Sikander Garg
Department of Pharmaceutical
Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Sudhir Varma
Department of Cardiology,
Sadbhavna Medical and Heart Institute, Patiala, Punjab, India.
Harpreet Singh Kalra
Department of Medicine,
Sadbhavna Medical and Heart Institute, Patiala, Punjab, India.
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