A Comparison of Rheumatoid Arthritis Patients in Kuwait with Other Populations: Results from the KRRD Registry | Chapter 07 | Innovations in Medicine and Medical Research Vol. 1
Objective:
Data on rheumatoid arthritis (RA) in Kuwait and The Middle East is scarce.
Available data from Western countries may not be representative of the region.
We describe RA patients in Kuwait and compare them with other RA populations
and with Kuwaiti general population.
Methods:
Adult RA patients from Kuwait Registry for Rheumatic Diseases (KRRD), the first
RA registry in The Middle East, were studied from February 2013 through
February 2015. Demographic, clinical and serologic data were compared with
other RA populations and with Kuwaiti general population.
Results:
835 patients were enrolled, 62.3% female. Mean age 50.6±12 years and disease
duration 6.1±6 years. RA was diagnosed at a mean age of 44.9±12 years. 17.1%
had family history of autoimmune rheumatic diseases. 3.1% had rheumatoid
nodules. Rheumatoid factor (RF) and anti-citrullinated peptide (ACPA) were
detected in 75.6% and 57.8%, respectively. Both were positive in 49% (r=0.287,
p=0.001). ANA was positive in 19.1%. Both ACPA and a combination of positive RF
and ACPA were more in males (p=0.017, 0.004 respectively), whereas ANA was more
in females (p=0.01). One third of male patients were smokers versus 1.9% of
females. Smoking was correlated to RF (p=0.009) and ACPA (p=0,002). Difference
in ACPA between genders was statistically explained by the predominance of
smoking in males. Comorbidities included diabetes mellitus (DM) (20.8%),
hypertension (20.2%), hyperlipidemia (10.5%) and coronary artery disease (CAD)
(3.1%). 4 cases of cancer were reported.
Conclusion:
RA population in Kuwait includes less women than other RA populations but more
than Kuwaiti general population. Family history is more common. A higher
positive ACPA in males was explained by smoking difference. Hypertension and
hyperlipidemia were less reported than in both Kuwaiti general population and
other RA populations. CAD was similar to other RA populations. DM was more
reported, reflecting its high background prevalence in Kuwait.
Author(s) Details
Dr. Adeeba Al-Herz
Amiri Hospital, Kuwait City,
Kuwait.
Adel Al-Awadhi
Department of Medicine,
Faculty of Medicine, Kuwait University, Kuwait.
Khulood Saleh
Farwania Hospital, Farwaniya
Governorate, Kuwait
Waleed Al-Kandari
Farwania Hospital, Farwaniya
Governorate, Kuwait.
Eman Hasan
Amiri Hospital, Kuwait City,
Kuwait.
Aqeel Ghanem
Mubarak Al-Kabeer Hospital,
Hawally Governorate, Kuwait.
Fatemah Abutiban
Jahra Hospital, Jahra
Governorate, Kuwait.
Ahmad Alenizi
Jahra Hospital, Jahra
Governorate, Kuwait.
Mohammed Hussain
Amiri Hospital, Kuwait City,
Kuwait.
Yaser Ali
Mubarak Al-Kabeer Hospital,
Hawally Governorate, Kuwait.
Ahmad Khadrawy
Farwania Hospital, Farwaniya
Governorate, Kuwait.
Ammad Fazal
Farwania Hospital, Farwaniya
Governorate, Kuwait.
Khaled Mokaddem
Amiri Hospital, Kuwait City,
Kuwait.
Beena Aftab
Jahra Hospital, Jahra
Governorate, Kuwait.
Najaf Haider
Jahra Hospital, Jahra
Governorate, Kuwait.
Ajaz Zaman
Mubarak Al-Kabeer Hospital,
Hawally Governorate, Kuwait.
Ghada Mazloum
Mubarak Al-Kabeer Hospital,
Hawally Governorate, Kuwait.
Youssef Bartella
Amiri Hospital, Kuwait City,
Kuwait.
Sally Hamed
Amiri Hospital, Kuwait City,
Kuwait.
Ahmed Al-Saber
Department of Mathematics
and Statistics, University of Strathclyde, Glasgow, Scotland.
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