Evaluation of Anti-diabetic Potentials of Methanol Extract of Ficus hispida Linn. Leaves against Alloxan Induced Diabetic Rats | Chapter 04 | Modern Advances in Pharmaceutical Research Vol. 3
Objective:
The present study was designed to evaluate the acute and chronic effects of the
methanol extract of Ficus hispida against alloxan (150 mg/kg) induced diabetic
rats.
Methods: In acute study,
hypoglycemic potency of methanol extract
of Ficus hispida was assessed by oral glucose tolerance test (OGTT) and in
chronic study of 21 days, extract at different doses (ie 100, 200 and 400
mg/kg) was screened for its
anti-diabetic activity. Blood glucose level had been estimated at 0, 7th,
14th and 21st and addition to this serum concentrations
of insulin, triglycerides, cholesterol, serum glutamate oxaloacetae
transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and urea
determined at 21st day of the study.
Results: In OGTT, standard
glibenclamide and extract (200 and 400 mg/kg) have shown significant reduction
in blood glucose level compared to control group. In chronic model, the
methanol extract was effective in reducing the blood glucose levels (P
<0.001) at higher dose (200 mg/kg and 400 mg/kg) and effect was comparable
to that of standard. The extract could also significantly (P<0.001) reduced
level of SGOT, triglycerides and cholesterol in serum and significantly
(P<0.001) increased the insulin level in blood which proves beneficial antidiabetic
potentials of the extract in diabetic model. The change in concentrations of
SGPT and urea were not significant (P>0.05).
Conclusion: The methanol extract of
Ficus hispida posses significant anti-diabetic activity in alloxan induced
diabetis in rats model.
Author(s) Details
Dr. V. D. Ravichandra
Department of Pharmacognosy,
East West College of Pharmacy, Bangalore-91, India.
Dr. Padmaa M. Paarakh
Department of Pharmacognosy,
The Oxford College of Pharmacy, Bangalore-68, India.
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