Prevalence of Clinically Concealed Prostatic Diseases at Post Mortem: A Teaching Hospital Experience in South-South, Nigeria | Chapter 03 | Innovations in Medicine and Medical Research Vol. 1
Background:
Most post-mortem studies on prostate gland are limited to malignant prostatic
tumours. The possibilities of finding other histological types of prostatic
diseases were worth exploring bearing in mind that Nodular hyperplasia and
cancer are of epidemiological importance.
Aim:
This study aims to determine the pattern of prostatic diseases at post-mortem
among individuals not previously diagnosed with prostate disease and who died
from other causes.
Materials
and Methods: Prostate glands at post-mortem were
obtained from individuals who died from non-prostate related causes, weighed,
fixed in 10% neutral buffered formalin, processed and histologically analysed.
Biodata and clinical diagnoses were obtained using clinical case notes and
post-mortem register.
Results:
The population under study were 86 adult males whose ages ranged from 30 to 85
years with a mean age of 52.71 ± 13.10 years. Ninety-three percent (93% / 80
cases) of the study population were afflicted with prostatic diseases at
post-mortem. The most common lesion was nodular hyperplasia. Latent or occult
adenocarcinoma followed this, prostatic intraepithelial neoplasia and
Schistosomiasis in decreasing order of frequency. The frequency of occult
adenocarcinoma, prostatic intraepithelial neoplasia (PIN) and nodular
hyperplasia increased significantly with age (P ≤ 0.05). The peak age for the
development of occult adenocarcinoma, PIN and nodular hyperplasia was in the
6th, 8th and 6th decades respectively.
Conclusion:
Clinically concealed prostatic diseases are common findings at post-mortem.
There is a significant increase (P ≤ 0.05) in the frequency of covert prostatic
diseases (nodular hyperplasia, PIN and adenocarcinoma) with advancing age.
Convert prostatic diseases especially nodular hyperplasia and prostatic
carcinoma have the potentials of contributing significantly to the burden of
health care and the cost of receiving treatment if the life expectancy improves
in our environment in particular and Nigeria in general.
Author(s) Details
E. Imasogie Dele
Department of Morbid
Anatomy, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria.
T. Azeke Akhator
Department of Anatomic
Pathology, Irrua Specialist Teaching Hospital, Nigeria.
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