Synthesis and Characterization of N-((tetrazol-5 yl)methyl)cyclohexanamine through 2D NMR Experiments: An Overview| Chapter 10 | Theory and Applications of Chemistry Vol. 4
Tetrazoles are an important class of nitrogen containing
heterocycles with a wide range of medicinal and commercial applications.
Tetrazolyl analogs of amino acids exhibit versatile biologic activity, and some
of them are known pharmaceuticals. In addition, compounds of this type may be
using in development of radiopharmaceuticals for positron emission tomography.
In continuation of our investigations in the tetrazolic
amino acids, we described in this presentation the synthesis and
characterization of some aminoalkyl and tetrazolic amino acid derivatives
basing on different spectroscopic methods as NMR 2D.
A simple synthetic approach to N-((tetrazol-5-yl)methyl)cyclohexanamine
in two steps starting from chloroacetonitrile and cyclohexylamine is reported.
The synthesized compound was characterized by 2D NMR spectroscopy (1H,
13C) and elemental analysis data.
Author(s) Details
Hassane Faraj
Organic Chemistry
Laboratory (LCO), Faculty of Sciences Dhar Mahraz, Sidi Mohammed Ben Abdellah
University, P.B. 2626, Fez 30000, Morocco.
Abdelilah El Hallaoui
Organic Chemistry
Laboratory (LCO), Faculty of Sciences Dhar Mahraz, Sidi Mohammed Ben Abdellah
University, P.B. 2626, Fez 30000, Morocco.
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