Combination Therapy in Treatment of Experimental Ischemic Heart Disease – A Preclinical Study | Chapter 13 | Trends in Pharmaceutical Research and Development Vol. 1
The
present study was designed to investigate the role of combined administration
of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion
injury in rat. Male Wistar albino rats were divided into five groups (= 6) and
treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and
the combination of both drugs, respectively 24 h before induction of global
ischemia (5 min of stabilization, 9 min of global ischemia and 12 min of
reflow). Combination of Ramipril and Candesartan when compared to the
monotherapy significantly increased the levels of superoxide dismutase, reduced
glutathione, catalase and nitric oxide and decreased the levels of
thiobarbituric acid reactive substances. In addition, the superior protective
role of combination of Ramipril and Candesartan on ischemia induced myocardial
damage was further confirmed by well preserved myocardial tissue architecture
in light microscopy and transmission electron microscopy analysis studies. The
combination was proved to be effective in salvaging the myocardial tissue
against ischemic reperfusion injury when compared to the monotherapy of
individual drugs and further investigations on protective mechanism of drugs by
increasing the nitric oxide level at molecular levels are needed.
Author (s) Details
Dr. Mohamed Saleem Thattakudian Sheikuduman
Department of Pharmacology, College of Pharmacy, Riyadh ELM University, P.O.Box 84891 Riyadh 11681, Kingdom of Saudi Arabia and Annamacharya College of Pharmacy, Rajampet-516126, Andhra Pradesh, India
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/156
Author (s) Details
Dr. Mohamed Saleem Thattakudian Sheikuduman
Department of Pharmacology, College of Pharmacy, Riyadh ELM University, P.O.Box 84891 Riyadh 11681, Kingdom of Saudi Arabia and Annamacharya College of Pharmacy, Rajampet-516126, Andhra Pradesh, India
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/156
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