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A Colour Doppler Study of Retrobulbar Blood Flow Parameters in Patients of Primary Open Angle Glaucoma: A Case Series from India | Chapter 17 | New Frontiers in Medicine and Medical Research Vol. 11

The purpose of this study was to compare the blood flow velocities in the Ophthalmic Artery, Central Retinal Artery, and Short Posterior Ciliary Arteries in patients with POAG and healthy subjects using Color Doppler Imaging, as well as to assess the effect of lowering intraocular pressure in POAG patients on retrobulbar blood flow.

Background: Raised intraocular pressure (IOP) is one of the risk factors for primary open angle glaucoma, according to the current definition. Another risk factor has been linked to changes in ocular blood flow. Furthermore, the eye being treated for glaucoma could be part of a larger systemic failure of auto-regulation of ocular blood flow. The designation of normal tension glaucoma as a clinical entity, as well as the observation of progressive glaucomatous damage despite IOP management, support this notion. The goal of this study was to look at retrobulbar blood flow in glaucoma patients using colour Doppler imaging (CDI) and evaluate how IOP control altered these parameters.

This is a prospective cohort study with 43 newly diagnosed POAG patients and 30 healthy controls. The ocular artery (OA), central retinal artery (CRA), and short posterior ciliary arteries were investigated for peak systolic velocity (PSV), mean end diastolic velocity (EDV), and resistivity index (RI) (SPCA). The results were compared to those of healthy individuals and patients with POAG before and after treatment.

Only in patients with POAG were mean PSV and EDV observed to be significantly lower in OA and CRA as compared to controls. Blood flow characteristics were identical to non-glaucomatous eyes once the goal pressure was reached.

Conclusions: Glaucomatous eyes have lower blood flow in retrobulbar arteries than the general population. Once the target pressure is reached, blood flow characteristics resemble those of non-glaucomatous eyes, indicating better blood flow as a result of lower IOP. In SPCA, colour Doppler imaging was proven to be unreliable for assessing blood flow. The role of RI as a reliable metric of blood flow resistance is unknown.


Author (S) Details

C. Sharma
Royal Derby Hospital, UK.

R. Saini
Royal Derby Hospital, UK.

M. D. Singh
Department of Ophthalmology Atal Bihari Vajpayee Institute of Medical Sciences and Dr. RML Hospital, New Delhi, India.

View Book :- https://stm.bookpi.org/NFMMR-V11/article/view/3703


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