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Study on Synthesis and Appraisal of Some 2,5-Disubstituted-1,3,4-Thiadiazoles as Diuretic Agents | Chapter 11 | New Innovations in Chemistry and Biochemistry Vol. 2

Acetazolamide and Methazolamide are diuretic 1,3,4-thiadiazole compounds that are well-known. As a result, certain novel 2,5-disubstituted-1,3,4-thiadiazoles were synthesised and diuretic efficacy was tested. The diuretic action of a handful of the compounds, including IVa1, IVb2, and IVc2, was comparable to that of the conventional medication acetazolamide. The Osiris property explorer software was used to calculate the properties of the synthesised compounds (peo). When compared to other analogues, morphilino analogues (IVa3 – IVd3) demonstrated higher Druglikeness and Drug Score. Because IVa3 is the most active morphilino analogue, it was chosen for a bioisosteric strategy for newer analogue design utilising molopt software.

Author (S) Details

Sanmati K. Jain
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, India.

Pradeep Mishra
Department of Pharmaceutical Sciences, GLA University, Mathura (UP), India.


View Book :- https://stm.bookpi.org/NICB-V2/article/view/3588


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