Skip to main content

Assessing the Correlation between Survivin and Bcl-2 Expression to Pathological Malignancy and Anti-apoptotic Property in Glial Cell Tumors | Chapter 12 | New Horizons in Medicine and Medical Research Vol. 6

 Apoptosis is controlled by a variety of variables whose mechanisms are unknown. Bcl-2 is a well-known apoptosis mediator. Survivin is also a new noble family inhibitor of apoptosis protein (IAP) that controls apoptosis in a different way than the Bcl-2 family. Survivin and Bcl-2 are found in a variety of human malignancies. The goal of the study was to look at the expression of survivin and Bcl-2 in glial cell tumours and see if there was a link between pathological malignancy and anti-apoptotic characteristics. This study looked at 58 patients who had glial cell tumours that had been surgically removed. The World Health Organization classification was used to classify the pathogenic kinds of glial cell tumours (WHO). Survivin was found in 60.3 percent of glioma samples, whereas Bcl-2 was found in 43.1 percent. Survivin and Bcl-2 were found to be co-expressed in 25.9% of tumour samples. Survivin expression was linked with pathological grade in astrocytic tumours (P 0.05), but not with Bcl-2 (P > 0.05). Anti-apoptosis was found in 91.4 percent, 92.0 percent, and 100 percent of patients with survivin, Bcl-2, or co-expression, respectively. These findings imply that survivin expression is linked to glioma pathological grades. Furthermore, in gliomas, survivin or Bcl-2 expression has a potent anti-apoptotic effect. Our findings suggest that survivin or Bcl-2 could be possible targets for glioma apoptosis.


Author(S) Details

Sae Min Kwon
Department of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

In-Suk Bae
Department of Neurosurgery, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.

Choong Hyun Kim
Department of Neurosurgery, Hanyang University Guri Hospital, Guri, Gyeonggi-do, Korea.

View Book:- https://stm.bookpi.org/NHMMR-V6/article/view/6443

Labels

Labels:

Comments

Post a Comment

Popular posts from this blog

Greening Regional Airports: A Vision for Carbon Neutral Infrastructure | Chapter 12 | Contemporary Perspective on Science, Technology and Research Vol. 3

 This study provides an overview of the energy demand of a regional airport, divided into individual time horizons. The electrification of aircraft systems raises the question of whether airports will be among the largest electricity consumers in our infrastructure in the future. Sustainability and especially emission reductions are significant challenges for airports that are currently being addressed. The Clean Sky 2 project GENESIS addresses the environmental sustainability of hybrid-electric 50-passenger aircraft systems in a life cycle perspective to support the development of a technology roadmap for the transition to sustainable and competitive electric aircraft systems. This article originates from the GENESIS research and describes various options for ground power supply at a regional airport. Potential solutions for airport infrastructure with a short (2030), medium (2040), and long (2050) time horizon are proposed. In addition to the environmental and conservation benefi...
Post a Comment
Read more

Occipital Dermal Sinus Tract Causing Craniospinal Infection: A Review | Chapter 13 | New Visions in Medicine and Medical Science Vol. 4

  Dermal sinus is a rare congenital condition characterized by a pathological tract connecting the skin to deeper tissues of the central nervous system, potentially leading to severe infectious complications. It arises from a failure in the separation of ectodermal layers during early gestation. Diagnosing dermal sinus tract in newborns requires a careful physical examination, focusing on midline dimples in the occipital region associated with cutaneous abnormalities like hairy nevus or hyperpigmentation. The presence of drainage, abnormal hair distribution, or localized swelling may indicate a sinus tract. Regular examination for dimples or sinuses is recommended for infants and children with recurrent meningitis or infections. Early detection is crucial to prevent severe complications like meningitis, with Staphylococcus aureus being a common causative organism. Neuroradiological studies, including computed tomography (CT) scan and magnetic resonance imaging (MRI), with histopath...
Post a Comment
Read more

Alkali Element Modification of Glucose Molecules as a Method to Dissolve Cancer Cells | Chapter 12 | New Visions in Medicine and Medical Science Vol. 4

  The present study highlights about alkali element modification of glucose molecules as a method to dissolve cancer cells. The central regulation of the mechanisms governing cell proliferation has little effect on cancer cells. Cancer cells are entirely independent of the central command and divide and proliferate on their own, making it challenging to activate their response mechanism. Precisely, this is the reason why they are at risk to the health of humans and/or any biological entities. Instead of trying to reconnect the central command of the growth control mechanism to cancer cells that are already out of the range, we present a method of using the cancer cell’s own irresponsive and uncontrolled growth mechanism to their disadvantage and destroy the cancer cells. We found that this is achievable in an atomic/molecular level study of the glucose molecule, which is the primary food source used for growth and energy generation by all cells in the body, including the cancer cel...
Post a Comment
Read more