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Chemo-Surveillance as a Natural Mechanism to Ensure Perfection of Wound Healing to Avoid Cancer Evolution and to Cure Cancer | Chapter 03 | New Horizons in Medicine and Medical Research Vol. 6

 The goal of this research is to look into the relationship between wound healing and cancer. The mechanics of wound healing, as well as the influence of wounds on cancer evolution and treatment, are discussed in this opinion piece. The proliferation and terminal differentiation (TD) of progenitor stem cells are required for wound healing (PSCs). PSCs (pluripotent stem cells) are pluripotent stem cells that can be differentiated into a variety of cells to aid wound healing. Wound healing is affected by compounds implicated in chemo-surveillance and cachexia. Prostaglandins (PGs) are produced in response to a wound, and they serve an important role in promoting the proliferation of PSCs in the early stages of the wound. Chemo-surveillance is used to induce PSC TD at the end of the wound healing process. The success of wound healing is determined on the effectiveness of chemo-surveillance. Because the functionality of chemo-surveillance is usually intact in healthy persons, wounds heal quickly and without much effort. The generation of tumour necrosis factor (TNF) is also triggered by wounds, which causes cachexia symptoms and the collapse of chemo-surveillance. PSCs' TD will be harmed, allowing them to develop into cancer stem cells (CSCs). Because PSCs' MEs are excessively active like cancer cells (CCs) due to their link with telomerase, it only takes a single hit to silence TET-1 enzyme and convert PSCs to CSCs, which is well within their reach. Wound healing and cancer progression are so intertwined that PSCs play a crucial role in both. If a wound is not adequately healed, cancer can develop. The greatest way for cancer treatment is to follow a successful wound healing process. Cachexia symptoms must be eliminated, chemo-surveillance restored, CSCs eliminated, differentiation blockade removed, and oncogenes and cancer suppressor genes deleted. The best options for meeting these needs are wound-healing metabolites.


Author(S) Details

Ming C. Liau
CDA Therapeutics, Inc., 3308 Sky Run Court, Missouri City, TX 77459, USA.

Christine Liau Craig
CDA Therapeutics, Inc., 3308 Sky Run Court, Missouri City, TX 77459, USA.

View Book:- https://stm.bookpi.org/NHMMR-V6/article/view/6434


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