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Serum Protein Levels in Oral Submucous Fibrosis Patients | Chapter 16 | New Horizons in Medicine and Medical Research Vol. 8

 The goal of this study was to examine total protein, albumin, and uric acid levels in patients with oral submucous fibrosis.

Patients were divided into three groups: Group I consisted of 25 healthy people, Group II consisted of 25 people who chewed tobacco but didn't have OSMF, and Group III consisted of 25 people who chewed tobacco but didn't have OSMF.

The mean serum levels of Total protein decreased from group I to group III, although the difference was not statistically significant. Albumin levels in the blood reduced from group I to group III, with statistically significant differences (p 0.05). Uric acid levels in the blood dropped from group I to group II, and the difference was statistically significant (p 0.05).

Local irritants such as capsaicin, nicotine, betel nut, punget, and spicy food, as well as chronic candidiasis, iron and nutritional inadequacies, human papillomavirus (HPV), genetic abnormalities, Herpes simplex virus (HSV), and human autoimmunity, can all contribute to OSMF. Areca nut, a component of betel quid, has been associated to an increase in the occurrence of OSMF in several case control studies. A decrease in serum protein levels is an important event that can cause oxidative stress to have deleterious consequences on our body's antioxidant defence system, resulting in precancerous transformation and other oral disorders. Our findings will be important not only in understanding the pathophysiology of OSMF, but also in developing antioxidant therapy methods and treating OSMF.


Author(S) Details

Sharique Ahmad
Department of Pathology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh-226003, India.

Tanish Baqar
Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh-226003, India.

Siddhartha Chandel
Department of Dentistry, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh-226003, India.

View Book:- https://stm.bookpi.org/NHMMR-V8/article/view/6654

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