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STK1p Based on the Serum Thymidine Kinase 1 as a Tumour Proliferation Marker Detected for Risk Assessment of Pre-carcinoma to Carcinoma Colorectal Progression: A Meta-Analysis | Chapter 02 | New Horizons in Medicine and Medical Research Vol. 8

 The goal of this study was to see if serum thymidine kinase 1 concentration (STK1p) could be used to predict the likelihood of progression from colorectal adenoma polyp/dysplasia to colorectal carcinoma using the TK1-IgY-pAb (CRC). The current meta-analysis looked at 25 papers that included patients with CRC (n=2,251), patients with colorectal polyp/dysplasia (n=1,165), and tumor-free controls (n=1,887). From January 1, 2009, to January 31, 2022, the publications were gathered from PubMed, Embase, CENTRAL, CNKI, WanFang, VIP, and SinoMed databases. To calculate the mean difference, articles were analysed using fixed or random effect models. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies that were gathered. The PRISMA statement was followed in the meta-analysis. STK1p was found to be a significant differentiator between tumor-free persons and those with CRC and colorectal adenoma polyp/dysplasia (p0.0001). Meanwhile, STK1p levels in CRC patients reduced by 34.1 percent within one month of surgery (p0.0001). This study found no evidence of considerable publication bias. The researchers found that TK1-IgY-pAb is a reliable biomarker for early diagnosis of colorectal adenoma polyp/dysplasia or pre-cancerous lesions, potentially preventing progression to colorectal carcinoma and giving the patient the highest chance of survival. Combining STK1p with colorectal-associated biomarkers, as well as determining tumour stage and grade, could be beneficial.


Author(S) Details

Ailian Hei
Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, 518110, China.

Jin Li
Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, 518110, China.

Ji Zhou
Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, 518110, China.

Ellen He
Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, 518110, China.

Sven Skog
Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, 518110, China.

View Book:- https://stm.bookpi.org/NHMMR-V8/article/view/6639
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