Simultaneous Determination of Camylofin Dihydrochloride and Paracetamol Using Differential Pulse Voltammetry in Micellar Media | Chapter 11 | New Insights on Chemical Research Vol. 1
Simple and sensitive differential pulse
voltammetric (DPV) method has been developed for simultaneous determination of
camylofin-2HCl and paracetamol. The electrochemical oxidation of camylofin was
studied at carbon paste electrode using cyclic and differential pulse
voltammetry. A reproducible and reliable oxidation current peak was obtained at
pH 7. The oxidation current was enhanced in presence of sodium dodecylsulphate
as an erosion reagent. Under optimal conditions the oxidation current was
proportional to camylofin concentration in the range from 5.0 to 100.0 µM.
Besides, the method was linear for paracetamol which is an active ingredient in
the concentration range from 5.0 to 1000.0 µM. The proposed DPV method was
selective for simultaneous determination of the two drugs with mean recovery of
99.58±2.13% and 99.44±0.57% for camylofin-2HCl and paracetamol, respectively.
The method was validated according to ICH guidelines and successfully applied
for the determination of the two drugs in combined pharmaceutical formulations.
Author(s) Details
Dr. Emad Mohamed Hussien
Department of Pharmaceutical
Chemistry, National Organization for Drug Control and Research (NODCAR), 9
Abou-Hazem Str., Giza, Egypt.
Dr. Israa Abd El-Ghafar
Mohammed
Department of Analytical
Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, 11754, Egypt.
Prof. Sawsan Abdel-Moneim
Abd El-Razeq
Department of Analytical
Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, 11754, Egypt.
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