STAT3 Mutations, Parasitic Infection and the IL-17 Pathway | Chapter 10 | Current Trends in Disease and Health Vol. 3
Parasitic infections may be commonly found in global distribution in
endemic areas. Parasitic infections are associated with a serum IgE response
and peripheral eosinophilia. Strongyloides and Ascaris infections are examples
of parasitic infections and pulmonary disease. The combined presence of
parasitic infections and high immunoglobulin level E (IgE) levels can be found
in isolation or as a clinical manifestation of certain immune defects.
The Hyper-IgE syndromes (HIES) as a group of
distinct primary immune disorders should be considered in the differential and
treatment of parasitic disease. The aim of this study was to highlight the importance
of recognizing underlying immune defects in the clinical setting of parasitic
infection, including HIES.
Author(s) Details
Amrita Dosanjh
Pediatric Respiratory,
UCSD Medical Center, San Diego, CA, USA.
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