Synthesis of Trans-3, 4-Dibenzyl-2-Oxo-Tetrahydrofuran: Advanced Study| Chapter 5 | Theory and Applications of Chemistry Vol. 4
Trans-3,4-dibenzyl-2-oxo-tetrahydrofuran (6) a substituted
tetrahydrofuranoid lignan was synthesized in 70% yield via the Stobbe
condensation between (1) benzaldehyde and (2) diethyl succinate. The structure
was confirmed by the spectral data such as infra-red, proton magnetic resonance
and mass spectrum. It has two similar but non equivalent aromatic groups which
appeared at δ: 6.48 - 6.76 and 7.06-7.25 as multiplets.
Author(s) Details –
Prof. I. R. Jack
Department
of Chemistry, Rivers State University of Science and Technology, P.M.B. 5080,
Port Harcourt, Nigeria.
Dr. K. O. Orubite
Department of Chemistry, Rivers State University of Science and Technology,
P.M.B. 5080, Port Harcourt, Nigeria.
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