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Determination of High Sensitivity C-Reactive Protein in Metabolic Syndrome | Chapter 12 | New Frontiers in Medicine and Medical Research Vol. 5

Background: If a person has metabolic syndrome, their risk of cardiovascular disease and type 2 diabetes mellitus is greatly elevated. In India, obesity and type 2 diabetes have become epidemics. Low-grade systemic inflammation characterises metabolic syndrome, which is a pro-inflammatory disease. C-reactive protein (CRP), a biomarker, is a reliable sign of chronic systemic inflammation. Higher levels of high sensitivity C-reactive protein (Hs-crp) have been associated to metabolic syndrome and its components, and can help predict future cardiovascular events. The following are the goals of the research: 1) The link between metabolic syndrome and high-sensitivity C reactive protein 2)An investigation of high-sensitivity C reactive protein as a surrogate measure of chronic inflammation in the metabolic syndrome. Methods and Materials The participants in this cross-sectional study included 50 patients with metabolic syndrome aged 18 and up, as well as 50 age and sex matched controls who came to the OPD or were admitted to the Bangalore Medical College medical department wards. Using the new IDF criteria, metabolic syndrome was identified. A fasting blood sample was obtained to determine the levels of hs-CRP, blood glucose, and lipid profile. The waist circumference, height, and weight were all the same. The values of several demographic characteristics such as BMI, waist circumference, blood pressure, and biochemical parameters such as blood sugar and lipid profile between cases and controls were statistically significant. With a p value of 0.001, patients with metabolic syndrome had a higher mean value of hs-CRP (8.31.04 vs 1.60.79mg/l). Conclusion: Patients with metabolic syndrome had significantly higher levels of hs-CRP when compared to controls, and hs-CRP levels grew linearly with the number of metabolic syndrome components. As a result, hs-CRP can most likely be used as a surrogate marker of chronic inflammation in patients with metabolic syndrome.

Author(s) Details

Prakash Kikkeri Gowdaiah
Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, India.

Dr. T. R. Mamatha
Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, India.

Dyaneshwar Nirgude
Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, India.
Irinel Popescu

Prakash Basappa Hosamani
Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, India.


View Book :- https://stm.bookpi.org/NFMMR-V5/article/view/3028

 

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