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Renal Function in Type 2 Diabetes Patients in Ile-Ife, Southwest Nigeria: A Clinicopathological Study | Chapter 15 | Highlights on Medicine and Medical Science Vol. 18

The goal of this study was to find out how common diabetic nephropathy is in type 2 diabetics in Southwest Nigeria, as well as the clinicopathological correlations.

Descriptive, cross-sectional study design.

Renal Unit, Medicine Department, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Southwest Nigeria, throughout the duration of the study.

Methodology: A percutaneous ultrasound-guided renal biopsy was performed on 40 consenting type 2 diabetic adults out of 88 patients with chronic kidney disease in stages 3 and 4 according to the Kidney Disease Improving Global Outcomes categorization.

Eighty-eight (48.1%) of the one hundred and eighty-three participants had clinical Diabetic Nephropathy, with a mean age of 58.05(6.10) years. Diabetes had been present for 9.55(4.1) years. Protein excretion was 0.55 g/day on average. Glomerular Filtration Rate was estimated to be 45.1(12) ml/min on average. Thirty-nine renal tissues (97.5%) had thickened glomerular basement membranes.The severity of glomerular lesions (r=0.480, p=0.002), interstitial alterations (p=0.602, r0.001), and vascular lesions all had a positive connection with systolic blood pressure (r=0.480, p=0.002) (0.429, 0.006). The glomerular lesions (r=0.500, p=0.001) and interstitial alterations (0.479, 0.002) were associated to diastolic blood pressure. The severity of glomerular lesions (r=0.457, p=0.003), vascular alterations (r=0.483, p=0.002), and diffuse glomerulosclerosis (r=0.407, p=0.009) were all linked to urinary protein excretion. Diabetic retinopathy was associated with glomerular lesion severity (r=0.406, p=0.009) and diffuse glomerulosclerosis (r=0.547, p0.001).

Conclusion: Diabetic nephropathy is very common among type 2 diabetics in Ile-Ife. The most common kidney pathology was glomerular basement membrane thickening. Blood pressure, protein excretion, retinopathy, and renal histology all had a favourable connection. Once diabetes mellitus has been diagnosed, treatment should be multidisciplinary.

 

 

Author (S) Details

Akinbodewa Ayodeji Akinwumi
Department of Medicine, Kidney Care Centre, University of Medical Sciences Teaching Hospital, Ondo State, Nigeria.

Okunola Oluyomi
Renal Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.

Adelusola A. Kayode
Department of Morbid Anatomy and Histopathalogy, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.

Sanusi Abubakr Abefe
Renal Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.

Arogundade Fatiu Abiola
Renal Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.

Ikem T. Rosemary
Endocrine Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.

Akinsola Adewale
Renal Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.


View Book :- https://stm.bookpi.org/HMMS-V18/article/view/3262
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