Study on Nanocomposites between PdNPs and Layered Double Hydroxides for Challenging Organometallic Catalysis | Chapter 1 | New Innovations in Chemistry and Biochemistry Vol. 2

A novel catalytic method based on palladium supported on layered-double hydroxide for the C-O activation of enol phosphates is demonstrated. The best catalytic results were obtained with hydrothermally treated LDH containing Pd(0). To examine the synthesis of -phenyl enecarbamates N-Boc/ CBz under Suzuki-Miyaura conditions, two distinct ketene aminal phosphates were employed as models. When compared to the CBz counterpart, the Boc substituted o-brominated enol phosphate was quite stable under catalytic conditions. The use of an ortho-bromo aniline as a precursor allowed for the arylation/ Heck cyclization of the 2-phenyl indole in modest yields. The heterocycle was synthesised in moderate yields for four consecutive runs thanks to the reusability of the catalyst.

Author (S) Details

Raquel V. Santos
Chemistry Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ 20550-900, Brazil.

Aires C. Silva
Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-903, Brazil.

Luiz Phelipe Tomasso
Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-903, Brazil.

Douglas G. de Lima
Chemistry Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ 20550-900, Brazil.

Alessandro B. C. Simas
Walter Mors Institute of Research on Natural Products, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-614, Brazil.

Luiz Fernando B. Malta
Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-903, Brazil.

Jaqueline D. Senra
Chemistry Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ 20550-900, Brazil.

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