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Tranexamic Coated or Eluted Uterine Balloon and Co Attached Cervical Shutter in Post Partum Haemorrhage. The First all in One Pharmaco-Mechanical Approach | Chapter 18 | New Frontiers in Medicine and Medical Research Vol. 3

The goal was to provide an economical, convenient gadget to the obstetrician's arsenal that includes all treatment techniques in one device with a feasible use, high efficacy, and safety, and a pharmacomechanical trinity of activities. A Tranexamic Acid (TXA) - Coated or Eluted Uterine Balloon is described herein for use in an intrauterine site for the primary therapy of postpartum haemorrhage (PPH). It augments the tamponade action of currently employed non-medicated uterine balloons with an inherent mechanism of local steady release of the antibrinolytic TXA into the uterine cavity, which has been shown to aid in haemostasis in PPH instances. The invention entails TXA coated or eluted balloons replenish non-medicated balloons with a TXA related – antifibrinolys therapeutic method, which is notably useful in haemorrhages linked with coagulopathy. This potential for TXA topical treatment rather than systemic injection has the benefit of eliminating the putative danger of thrombosis associated with TXA. Furthermore, drug coating of the balloon surface is not restricted to TXA; additional haemostatics and coagulants such as thrombin, fibrinogen, and activated F11v may also be used. Furthermore, this invention provides a novel solution to the technological challenge of maintaining the released medicine inside an open hollow uterine cavitation. The latter was created to ensure long-term residence and effective drug transfer into the uterine cavity, resulting in continuous and effective TXA administration at the site of action. Furthermore, the cervical shutter provides extra counterpressure to the lower uterine section, which can be a bleeding location in the event of an improperly attached placenta.


Author (S) Details

Abd el aal Nasser Kamal
Department of Obstetrics & Gynecology, Menoufia Faculty of Medicine, Egypt.


View Book :- https://stm.bookpi.org/NFMMR-V3/article/view/3153

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